D'Amato F., Eldin C., Raoult Didier. (2016). The contribution of genomics to the study of Q fever. Future Microbiology, 11 (2), p. 253-272. ISSN 1746-0913.
Titre du document
The contribution of genomics to the study of Q fever
Future Microbiology, 2016,
11 (2), p. 253-272 ISSN 1746-0913
Coxiella burnetii is the etiological agent of Q fever, a worldwide zoonosis that can result in large outbreaks. The birth of genomics and sequencing of C. burnetii strains has revolutionized many fields of study of this infection. Accurate genotyping methods and comparative genomic analysis have enabled description of the diversity of strains around the world and their link with pathogenicity. Genomics has also permitted the development of qPCR tools and axenic culture medium, facilitating the diagnosis of Q fever. Moreover, several pathophysiological mechanisms can now be predicted and therapeutic strategies can be determined thanks to in silico genome analysis. An extensive pan-genomic analysis will allow for a comprehensive view of the clonal diversity of C. burnetii and its link with virulence.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Biotechnologies [084]
