@article{PAR00014304, title = {{T}he contribution of genomics to the study of {Q} fever}, author = {{D}'{A}mato, {F}. and {E}ldin, {C}. and {R}aoult, {D}idier}, editor = {}, language = {{ENG}}, abstract = {{C}oxiella burnetii is the etiological agent of {Q} fever, a worldwide zoonosis that can result in large outbreaks. {T}he birth of genomics and sequencing of {C}. burnetii strains has revolutionized many fields of study of this infection. {A}ccurate genotyping methods and comparative genomic analysis have enabled description of the diversity of strains around the world and their link with pathogenicity. {G}enomics has also permitted the development of q{PCR} tools and axenic culture medium, facilitating the diagnosis of {Q} fever. {M}oreover, several pathophysiological mechanisms can now be predicted and therapeutic strategies can be determined thanks to in silico genome analysis. {A}n extensive pan-genomic analysis will allow for a comprehensive view of the clonal diversity of {C}. burnetii and its link with virulence.}, keywords = {{C}oxiella burnetii ; genomics ; pan-genome ; {Q} fever ; virulence}, booktitle = {}, journal = {{F}uture {M}icrobiology}, volume = {11}, numero = {2}, pages = {253--272}, ISSN = {1746-0913}, year = {2016}, DOI = {10.2217/fmb.15.137}, URL = {https://www.documentation.ird.fr/hor/{PAR}00014304}, }