@article{fdi:010084427,
  title = {{C}ancer de higado : antigua o nueva amenaza para los jovenes de paises en via de desarrollo ?},
  author = {{C}erapio, {J}.{P}. and {C}ontreras-{M}ancilla, {J}. and {F}ernandez, {R}. and {F}ournie, {J}.{J}. and {D}eharo, {E}ric and {B}ertani, {S}t{\'e}phane and {P}ineau, {P}. and {C}asavilca-{Z}ambrano, {S}. and {R}uiz, {E}.},
  editor = {},
  language = {{SPA}},
  abstract = {{E}ntre las neoplasias malignas más frecuentes del mundo, el carcinoma hepatocelular ({CHC}) es la segunda causa de muerte relacionada con el cáncer (1). {S}u incidencia se ha duplicado durante las dos últimas d{\'e}cadas y la mayor carga se produce en los países de ingresos bajos y medianos. {L}os tumores hepáticos primarios malignos suelen describirse como una patología que afecta principalmente a hombres mayores de 40 años con un hígado cirrótico; rara vez se han registrado en personas más jóvenes y normalmente, en menores de 40, lo más común es el hepatoblastoma.},
  keywords = {{PEROU}},
  booktitle = {},
  journal = {{R}evista {P}eruana de {C}iencias de la {S}alud},
  volume = {4},
  numero = {1},
  pages = {5--8},
  ISSN = {2707-6946},
  year = {2022},
  DOI = {10.37711/rpcs.2022.4.1.362},
  URL = {https://www.documentation.ird.fr/hor/fdi:010084427},
}

@article{fdi:010086874,
  title = {{E}stimating the burden of hepatitis {B} virus infection in {L}aos between 2020 and 2021 : a cross-sectional seroprevalence survey},
  author = {{S}itbounlang, {P}. and {D}eharo, {E}ric and {L}atthaphasavang, {V}atthanaphone and {M}archio, {A}. and {S}oukhsakhone, {C}. and {S}oinxay, {V}. and {M}ayxay, {M}. and {S}teenkeste, {N}. and {V}incelot, {P}. and {B}ertani, {S}t{\'e}phane and {P}alamy, {S}. and {P}aboriboune, {P}. and {P}ineau, {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {L}aos is considered highly endemic for persistent infection with hepatitis {B} virus ({HBV}). {T}o eliminate this burden, it has gradually implemented universal anti-hepatitis {B} immunisation of newborns over the past two decades. {M}ethods {U}sing {VIKIA} ({R}) {HB}s{A}g, a rapid test for the qualitative detection of the {HBV} surface antigen, we conducted between {S}ep 1st, 2020 and {A}ug 31st, 2021 the largest prospective prevalence survey ever in {L}aos. {T}his survey included blood donors ({BD}, n = 42,277), patients attending care in capital and provincial hospitals (n = 37,347) including attending mothers (n = 20,548), {HIV}-infected patients (n = 7439, recruited from 2009 to 2020), students from the {H}ealth {S}ciences {U}niversity (n = 609), and outpatients (n = 350) coming for diagnosis at the {C}enter {I}nfectiology {L}ao-{C}hristophe {M}erieux in {V}ientiane. {I}n total, 88,022 persons were tested, representing approximately 1.22% of the national population. {T}o reach a reasonable estimate of {HB}s{A}g prevalence in {L}aos, we segmented the population according to three variables, age (=20 years as a cut-off), sex, and geographical origin. {BD} values were used to estimate {HB}s{A}g prevalence in patients aged <20 while hospital survey prevalence was used to estimate the prevalence in those aged older than 20 years. {F}indings {W}e observed an {HB}s{A}g seroprevalence ranging from 2.6% in blood donors to 8.0% in {HIV}-infected patients. {I}n {BD}, men were significantly more at risk to be carriers than women ({RR} = 1.2, {P} = 0.00063). {F}or {BD}, attendingmothers, or {HIV}-infected patients, {HB}s{A}g was significantly more prevalent in northern {L}aos (5.1-8.4%) than in central (2.0-8.1%) or southern parts of the country (2.2- 6.9%), thereby delineating a {N}orth-to-{S}outh gradient. {I}nterpretation {W}e considered that {HB}s{A}g prevalence probably ranges between 5.0% and 6.0% of the total population. {T}hus, we consider that {L}aos may no longer be highly endemic for chronic {HBV} infection but rather a country with intermediate endemicity.},
  keywords = {{H}epatitis {B} virus ; {S}outheast {A}sia ; {L}aos ; {E}ndemic country ; {U}niversal ; {I}mmunization ; {LAOS}},
  booktitle = {},
  journal = {e{C}linical{M}edicine},
  volume = {52},
  numero = {},
  pages = {101582 [12 p.]},
  year = {2022},
  DOI = {10.1016/j.eclinm.2022.101582},
  URL = {https://www.documentation.ird.fr/hor/fdi:010086874},
}

@article{fdi:010085857,
  title = {{E}xcess mortality in patients with cancer during the {COVID}-19 pandemic in {P}eru : an analysis of death registry data [r{\'e}sum{\'e}]},
  author = {{V}idaurre, {T}. and {E}nriquez-{V}era, {D}. and {B}ertani, {S}t{\'e}phane},
  editor = {},
  language = {{ENG}},
  abstract = {},
  keywords = {{PEROU}},
  booktitle = {},
  journal = {{L}ancet {O}ncology},
  volume = {23},
  numero = {{S}pecial {I}ssue 1},
  pages = {{S}28},
  ISSN = {1470-2045},
  year = {2022},
  URL = {https://www.documentation.ird.fr/hor/fdi:010085857},
}

@article{fdi:010085993,
  title = {{E}xposure assessment of 170 pesticide ingredients and derivative metabolites in people from the {C}entral {A}ndes of {P}eru},
  author = {{H}onles, {J}. and {C}lisson, {C}. and {M}onge, {C}. and {V}asquez-{O}cmin, {P}. and {C}erapio, {J}. {P}. and {P}alamy, {S}. and {C}asavilca-{Z}ambrano, {S}. and {H}errera, {J}avier and {P}ineau, {P}. and {D}eharo, {E}ric and {P}eynet, {V}. and {B}ertani, {S}t{\'e}phane},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he {C}entral {A}ndes of {P}eru are a region of great concern regarding pesticide risk to the health of local communities. {T}herefore, we conducted an observational study to assess the level of pesticide contamination among {A}ndean people. {A}nalytical chemistry methods were used to measure the concentrations of 170 pesticide-related compounds in hair samples from 50 adult {A}ndean subjects living in rural and urban areas. {A}s part of the study, a questionnaire was administered to the subjects to collect information regarding factors that increase the risk of pesticide exposure. {O}ur results indicate that {A}ndean people are strongly exposed to agrochemicals, being contaminated with a wide array of pesticide-related compounds at high concentration levels. {M}ultivariate analyses and geostatistical modeling identified sociodemographic factors associated with rurality and food origin that increase pesticide exposure risk. {T}he present study represents the first comprehensive investigation of pesticide-related compounds detected in body samples collected from people living in the {C}entral {A}ndes of {P}eru. {O}ur findings pinpoint an alarming environmental situation that threatens human health in the region and provide a rationale for improving public policies to protect local communities.},
  keywords = {{PEROU} ; {ANDES}},
  booktitle = {},
  journal = {{S}cientific {R}eports - {N}ature},
  volume = {12},
  numero = {1},
  pages = {13525 [15 p.]},
  ISSN = {2045-2322},
  year = {2022},
  DOI = {10.1038/s41598-022-17772-1},
  URL = {https://www.documentation.ird.fr/hor/fdi:010085993},
}

@article{fdi:010085215,
  title = {{S}urvival after curative pancreaticoduodenectomy for ampullary adenocarcinoma in a {S}outh {A}merican population : a retrospective cohort study},
  author = {{F}ernandez-{P}lacencia, {R}. {M}. and {M}ontenegro, {P}. and {G}uerrero, {M}. and {S}errano, {M}. and {O}rtega, {E}. and {B}ravo, {M}. and {H}uanca, {L}. and {B}ertani, {S}t{\'e}phane and {T}rejo, {J}. {M}. and {W}ebb, {P}. and {M}alca-{V}asquez, {J}. and {T}axa, {L}. and {L}achos-{D}avila, {A}. and {C}elis-{Z}apata, {J}. and {L}uque-{V}asquez, {C}. and {P}ayet, {E}. and {R}uiz, {E}. and {B}errospi, {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{BACKGROUND} {A}mpullary adenocarcinoma ({AAC}) is a rare neoplasm that accounts for only 0.2% of all gastrointestinal cancers. {I}ts incidence rate is lower than 6 cases per million people. {D}ifferent prognostic factors have been described for {AAC} and are associated with a wide range of survival rates. {H}owever, these studies have been exclusively conducted in patients originating from {A}sian, {E}uropean, and {N}orth {A}merican countries. {AIM} {T}o evaluate the histopathologic predictors of overall survival ({OS}) in {S}outh {A}merican patients with {AAC} treated with curative pancreaticoduodenectomy ({PD}). {METHODS} {W}e analyzed retrospective data from 83 {AAC} patients who underwent curative ({R}0) {PD} at the {N}ational {C}ancer {I}nstitute of {P}eru between {J}anuary 2010 and {O}ctober 2020 to identify histopathologic predictors of {OS}. {RESULTS} {S}ixty-nine percent of patients had developed intestinal-type {AAC} (69%), 23% had pancreatobiliary-type {AAC}, and 8% had other subtypes. {F}orty-one percent of patients were classified as {S}tage {I}, according to the {AJCC} 8th {E}dition. {R}ecurrence occurred primarily in the liver (n = 8), peritoneum (n = 4), and lung (n = 4). {S}tatistical analyses indicated that {T}3 tumour stage [hazard ratio ({HR}) of 6.4, 95% confidence interval ({CI}) of 2.5-16.3, {P} < 0.001], lymph node metastasis ({HR}: 4.5, 95%{CI}: 1.8-11.3, {P} = 0.001), and pancreatobiliary type ({HR}: 2.7, 95%{CI}: 1.2-6.2, {P} = 0.025) were independent predictors of {OS}. {CONCLUSION} {E}xtended tumour stage ({T}3), pancreatobiliary type, and positive lymph node metastasis represent independent predictors of a lower {OS} rate in {S}outh {A}merican {AAC} patients who underwent curative {PD}.},
  keywords = {{G}astrointestinal neoplasms ; {A}denocarcinoma ; {A}mpulla ; {P}ancreaticoduodenectomy ; {S}urvival ; {S}outh {A}merica ; {PEROU}},
  booktitle = {},
  journal = {{W}orld {J}ournal of {G}astrointestinal {S}urgery},
  volume = {14},
  numero = {1},
  pages = {24--35},
  ISSN = {1948-9366},
  year = {2022},
  DOI = {10.4240/wjgs.v14.i1.24},
  URL = {https://www.documentation.ird.fr/hor/fdi:010085215},
}

@article{fdi:010082443,
  title = {{A} preoperative nomogram for predicting long-term survival after resection of large hepatocellular carcinoma (sup. 10 cm)},
  author = {{R}uiz, {E}. and {P}ineau, {P}. and {F}lores, {C}. and {F}ernández, {R}. and {C}ano, {L}. and {C}erapio, {J}.{P}. and {C}asavilca-{Z}ambrano, {S}. and {B}errospi, {F}. and {C}hávez, {I}. and {R}oche, {B}enjamin and {B}ertani, {S}t{\'e}phane},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {I}t has previously been demonstrated that a fraction of patients with hepatocellular carcinoma ({HCC}) sup. 10 cm can benefit from liver resection. {H}owever, there is still a lack of effective decision-making tools to inform intervention in these patients. {M}ethods: {W}e analysed a comprehensive set of clinical data from 234 patients who underwent liver resection for {HCC} sup.10 cm at the {N}ational {C}ancer {I}nstitute of {P}eru between 1990 and 2015, monitored their survival, and constructed a nomogram to predict the surgical outcome based on preoperative variables. {R}esults: {W}e identified cirrhosis, multifocality, macroscopic vascular invasion, and spontaneous tumour rupture as independent predictors of survival and integrated them into a nomogram model. {T}he nomogram's ability to forecast survival at 1, 3, and 5 years was subsequently confirmed with high concordance using an internal validation. {T}hrough applying this nomogram, we stratified three groups of patients with different survival probabilities. {C}onclusion: {W}e constructed a preoperative nomogram to predict long-term survival in patients with {HCC} sup.10 cm. {T}his nomogram is useful in determining whether a patient with large {HCC} might truly benefit from liver resection, which is paramount in low- and middle-income countries where {HCC} is often diagnosed at advanced stages.},
  keywords = {{PEROU}},
  booktitle = {},
  journal = {{HPB}},
  volume = {24},
  numero = {2},
  pages = {192--201},
  ISSN = {1365-182{X}},
  year = {2022},
  DOI = {10.1016/j.hpb.2021.06.006},
  URL = {https://www.documentation.ird.fr/hor/fdi:010082443},
}

@article{fdi:010082444,
  title = {{G}lobal {DNA} hypermethylation pattern and unique gene expression signature in liver cancer from patients with {I}ndigenous {A}merican ancestry},
  author = {{C}erapio, {J}.{P}. and {M}archio, {A}. and {C}ano, {L}. and {L}ópez, {I}. and {F}ourni{\'e}, {J}.{J}. and {R}{\'e}gnault, {B}. and {C}asavilca-{Z}ambrano, {S}. and {R}uiz, {E}. and {D}ejean, {A}. and {B}ertani, {S}t{\'e}phane and {P}ineau, {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{H}epatocellular carcinoma ({HCC}) usually afflicts individuals in their maturity after a protracted liver disease. {C}ontrasting with this pattern, the age structure of {HCC} in {A}ndean people displays a bimodal distribution with half of the patients developing {HCC} in adolescence and early adulthood. {T}o deepen our understanding of the molecular determinants of the disease in this population, we conducted an integrative analysis of gene expression and {DNA} methylation in {HCC} developed by 74 {P}eruvian patients, including 39 adolescents and young adults. {W}hile genome-wide hypomethylation is considered as a paradigm in human {HCC}s, our analysis revealed that {P}eruvian tumors are associated with a global {DNA} hypermethylation. {M}oreover, pathway enrichment analysis of transcriptome data characterized an original combination of signatures. {P}eruvian {HCC} forgoes canonical activations of {IGF}2, {N}otch, {R}as/{MAPK}, and {TGF}-? signals to depend instead on {H}ippo/{YAP}1, {MYC}, and {W}nt/?-catenin pathways. {T}hese signatures delineate a homogeneous subtype of liver tumors at the interface of the proliferative and non-proliferative classes of {HCC}s. {R}emarkably, the development of this {HCC} subtype occurs in patients with one of the four {N}ative {A}merican mitochondrial haplogroups {A}-{D}. {F}inally, integrative characterization revealed that {P}eruvian {HCC} is apparently controlled by the {PRC}2 complex that mediates cell reprogramming with massive {DNA} methylation modulating gene expression and pinpointed retinoid signaling as a potential target for epigenetic therapy.},
  keywords = {{PEROU}},
  booktitle = {},
  journal = {{O}ncotarget},
  volume = {12},
  numero = {5},
  pages = {475--492},
  ISSN = {1949-2553},
  year = {2021},
  DOI = {10.18632/oncotarget.27890},
  URL = {https://www.documentation.ird.fr/hor/fdi:010082444},
}

@article{fdi:010083800,
  title = {{C}annabinoids vs. whole metabolome : relevance of cannabinomics in analyzing {C}annabis varieties},
  author = {{V}asquez-{O}cmin, {P}. {G}. and {M}arti, {G}. and {B}onhomme, {M}. and {M}athis, {F}. and {F}ournier, {S}. and {B}ertani, {S}t{\'e}phane and {M}aciuk, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{C}annabis sativa has a long history of domestication both for its bioactive compounds and its fibers. {T}his has produced hundreds of varieties, usually characterized in the literature by chemotypes, with {D}elta(9)-{THC} and {CBD} content as the main markers. {H}owever, chemotyping could also be done based on minor compounds (phytocannabinoids and others). {I}n this work, a workflow, which we propose to name cannabinomics, combines mass spectrometry of the whole metabolome and statistical analysis to help differentiate {C}. sativa varieties and deciphering their characteristic markers. {B}y applying this cannabinomics approach to the data obtained from 20 varieties of {C}. sativa (classically classified as chemotype {I}, {II}, or {III}), we compared the results with those obtained by a targeted quantification of 11 phytocannabinoids. {C}annabinomics can be considered as a complementary tool for phenotyping and genotyping, allowing the identification of minor compounds playing a key role as markers of differentiation.},
  keywords = {{C}annabis ; {C}annabinomics ; {C}hemotypes ; {M}etabolome ; {P}hytocannabinoids},
  booktitle = {},
  journal = {{A}nalytica {C}himica {A}cta},
  volume = {1184},
  numero = {},
  pages = {339020 [12 p.]},
  ISSN = {0003-2670},
  year = {2021},
  DOI = {10.1016/j.aca.2021.339020},
  URL = {https://www.documentation.ird.fr/hor/fdi:010083800},
}

@article{fdi:010083797,
  title = {{S}ingle-cell {RNA}seq profiling of human gamma delta {T} lymphocytes in virus-related cancers and {COVID}-19 disease},
  author = {{C}erapio, {J}. {P}. and {P}errier, {M}. and {P}ont, {F}. and {T}osolini, {M}. and {L}aurent, {C}. and {B}ertani, {S}t{\'e}phane and {F}ournie, {J}. {J}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he detailed characterization of human gamma delta {T} lymphocyte differentiation at the single-cell transcriptomic (sc{RNA}seq) level in tumors and patients with coronavirus disease 2019 ({COVID}-19) requires both a reference differentiation trajectory of gamma delta {T} cells and a robust mapping method for additional gamma delta {T} lymphocytes. {H}ere, we incepted such a method to characterize thousands of gamma delta {T} lymphocytes from (n = 95) patients with cancer or adult and pediatric {COVID}-19 disease. {W}e found that cancer patients with human papillomavirus-positive head and neck squamous cell carcinoma and {E}pstein-{B}arr virus-positive {H}odgkin's lymphoma have gamma delta tumor-infiltrating {T} lymphocytes that are more prone to recirculate from the tumor and avoid exhaustion. {I}n {COVID}-19, both {TCRV} gamma 9 and {TCRV} gamma non9 subsets of gamma delta {T} lymphocytes relocalize from peripheral blood mononuclear cells ({PBMC}) to the infected lung tissue, where their advanced differentiation, tissue residency, and exhaustion reflect {T} cell activation. {A}lthough severe {COVID}-19 disease increases both recruitment and exhaustion of gamma delta {T} lymphocytes in infected lung lesions but not blood, the anti-{IL}6{R} therapy with {T}ocilizumab promotes gamma delta {T} lymphocyte differentiation in patients with {COVID}-19. {PBMC} from pediatric patients with acute {COVID}-19 disease display similar gamma delta {T} cell lymphopenia to that seen in adult patients. {H}owever, blood gamma delta {T} cells from children with the {COVID}-19-related multisystem inflammatory syndrome are not lymphodepleted, but they are differentiated as in healthy {PBMC}. {T}hese findings suggest that some virus-induced memory gamma delta {T} lymphocytes durably persist in the blood of adults and could subsequently infiltrate and recirculate in tumors.},
  keywords = {human ; gammadelta ; lymphocyte ; tumor ; {COVID}-19 ; transcriptome ; single cell ; differentiation ; trajectory},
  booktitle = {},
  journal = {{V}iruses},
  volume = {13},
  numero = {11},
  pages = {2212 [14 p.]},
  year = {2021},
  DOI = {10.3390/v13112212},
  URL = {https://www.documentation.ird.fr/hor/fdi:010083797},
}

@article{fdi:010082679,
  title = {{M}etallomic profile in non-cirrhotic hepatocellular carcinoma supports a phenomenon of metal metabolism adaptation in tumor cells},
  author = {{C}ano, {L}. and {B}ertani, {S}t{\'e}phane and {I}sland, {M}. {L}. and {C}erapio, {J}. {P}. and {R}uiz, {E}. and {P}ineau, {P}. and {M}onbet, {V}. and {B}oudjema, {K}. and {T}axa, {L}. and {C}asavilca-{Z}ambrano, {S}. and {R}opert, {M}. and {T}urlin, {B}. and {L}oreal, {O}.},
  editor = {},
  language = {{ENG}},
  abstract = {{W}e have previously described a form of hepatocellular carcinoma ({HCC}) in non-cirrhotic liver ({HCC}-{NC}) developed by {P}eruvian patients. {W}e analyzed the metallomic profile in hepatic tissues from two independent cohorts exhibiting {HCC}-{NC}. {C}linical, histopathological data, and {HCC} and non-tumoral liver ({NTL}) samples of 38 {P}eruvian and 38 {F}rench {HCC}-{NC} patients, were studied. {T}welve metals were quantified using {ICP}/{MS}: {M}n, {F}e, {C}u, {C}o, {Z}n, {A}s, {S}e, {R}b, {M}o, {C}d, {P}b, and {S}n. {A}ssociations between metals and survival were assessed. {O}ur data showed significant differences between cohorts. {M}ean ages were 40.6 +/- 20, 67.5 +/- 9 years old for {P}eruvians and {F}rench, respectively. {F}ifty percent of the {P}eruvian patients were positive for the {HB}s{A}g, versus 3% in {F}rench patients. {M}n, {C}u, {Z}n, {A}s, {S}e, {R}b, {M}o, {C}d, {S}n metal concentrations were higher in {NTL} of {P}eruvians. {I}mportantly, metal concentrations were lower in {HCC} areas compared to {NTL} tissues in both cohorts, except for {C}u for which mean concentration was higher in {HCC} (p<0.05). {S}e concentration in {HCC} was associated with extended survival only in {P}eruvians. {O}ur data, obtained in {P}eruvian and {F}rench {HCC}-{NC} cohorts, highlights similarity in the metallomic profile of {HCC} compared to {NTL} during the hepatic tumorigenesis in these specific groups of patients.},
  keywords = {{PEROU} ; {FRANCE}},
  booktitle = {},
  journal = {{S}cientific {R}eports - {N}ature},
  volume = {11},
  numero = {1},
  pages = {14195 [10 p.]},
  ISSN = {2045-2322},
  year = {2021},
  DOI = {10.1038/s41598-021-93369-4},
  URL = {https://www.documentation.ird.fr/hor/fdi:010082679},
}

@article{fdi:010081069,
  title = {{N}atural occurrence of mycotoxin-producing fusaria in market-bought {P}eruvian cereals : a food safety threat for {A}ndean populations},
  author = {{D}ucos, {C}. and {P}inson-{G}adais, {L}. and {C}hereau, {S}. and {R}ichard-{F}orget, {F}. and {V}asquez-{O}cmin, {P}. and {C}erapio, {J}. {P}. and {C}asavilca-{Z}ambrano, {S}. and {R}uiz, {E}. and {P}ineau, {P}. and {B}ertani, {S}t{\'e}phane and {P}onts, {N}.},
  editor = {},
  language = {{ENG}},
  abstract = {{C}onsumption of cereals contaminated by mycotoxins poses health risks. {F}or instance, {F}umonisins {B}, mainly produced by {F}usarium verticillioides and {F}usarium proliferatum, and the type {B} trichothecene deoxynivalenol, typically produced by {F}usarium graminearum, are highly prevalent on cereal grains that are staples of many cultural diets and known to represent a toxic risk hazard. {I}n {P}eru, corn and other cereals are frequently consumed on a daily basis under various forms, the majority of food grains being sold through traditional markets for direct consumption. {H}ere, we surveyed mycotoxin contents of market-bought grain samples in order to assess the threat these mycotoxins might represent to {P}eruvian population, with a focus on corn. {W}e found that nearly one sample of {P}eruvian corn out of six was contaminated with very high levels of {F}umonisins, levels mostly ascribed to the presence of {F}. verticillioides. {E}xtensive profiling of {P}eruvian corn kernels for fungal contaminants could provide elements to refine the potential risk associated with {F}usarium toxins and help define adapted food safety standards.},
  keywords = {{F}umonisins {B} ; {P}eru ; corn ; {PEROU}},
  booktitle = {},
  journal = {{T}oxins},
  volume = {13},
  numero = {2},
  pages = {172 [15 p.]},
  year = {2021},
  DOI = {10.3390/toxins13020172},
  URL = {https://www.documentation.ird.fr/hor/fdi:010081069},
}

@article{fdi:010079998,
  title = {{D}epression in women with a diagnosis of breast cancer. {P}revalence of symptoms of depression in {P}eruvian women with early breast cancer and related sociodemographic factors},
  author = {{C}asavilca-{Z}ambrano, {S}. and {C}ustodio, {N}. and {L}iendo-{P}icoaga, {R}. and {C}ancino-{M}aldonado, {K}. and {E}senarro, {L}. and {M}ontesinos, {R}. and {B}ertani, {S}t{\'e}phane and {F}ejerman, {L}. and {G}uerchet, {M}. and {V}idaurre, {T}.},
  editor = {},
  language = {{ENG}},
  abstract = {{W}e sought to review literature on the prevalence of symptoms of depression in women with a diagnosis of breast cancer ({BC}) and in the {P}eruvian population determine the prevalence of symptoms of depression and to describe the association with sociodemographic characteristics. {D}escriptive cross-sectional analytical study of 254 patients from the {N}ational {C}ancer {I}nstitute of {P}eru ({I}nstituto {N}acional de {E}nfermedades {N}eoplasicas) with a diagnosis of clinical stage {I} or {II} {BC}. {T}he patients included women aged between 26 and 67 years old. {S}ymptoms of depression were monitored by the {B}eck {D}epression {I}nventory-{II}. {M}oreover, clinical features and patient sociodemographic characteristics were analyzed and their association with depression was assessed by logistic regression. {T}he average age of the patients was 47.8 +/- 9.2 years; 5.4% of the patients were postmenopausal at the time of the questionnaire. {A}bout 55% of women were from {L}ima, 58.3% had completed secondary education (11 +/- 3.2 years), 45.7% were not working, and 46.5% were single. {T}he prevalence of depression was 25.6% at the time of {BC} diagnosis. {O}f those patients with symptoms of depression, 16.9% showed symptoms of mild depression, 6.3% moderate, and 2.4% severe. {A} multivariable logistic regression model showed that in {P}eruvian women with a diagnosis of {BC} being married or employed significantly decreased the odds of presenting depressive symptoms ({P}=0.029 and 0.017, respectively). {O}ur main limitation was the lack of evaluation of depressive symptoms before the diagnosis, during or at the end of treatment. {A}nother limitation was that the {B}eck {D}epression {I}nventory-{II} test could only identify depressive symptoms, but not depression as a disease. {W}e have reviewed relevant literature on depression in women with a diagnosis of {BC}. {T}he data presented suggests an association between both employment and marital status with depressive symptoms among {P}eruvian women with a diagnosis of {BC}. {P}re-emptive support for women at risk could influence resilience and/or motivation for compliance with antineoplastic treatments.},
  keywords = {{D}epression ; {B}reast cancer ; {P}sychiatric ; {B}eck depression inventory-{II} ; ({BDI}-{II}) ; {S}tages {I} and {II} breast cancer ; {E}arly stage breast cancer ; {PEROU}},
  booktitle = {},
  journal = {{S}eminars in {O}ncology},
  volume = {47},
  numero = {5},
  pages = {293--301},
  ISSN = {0093-7754},
  year = {2020},
  URL = {https://www.documentation.ird.fr/hor/fdi:010079998},
}

@article{fdi:010077041,
  title = {{O}n hepatocellular carcinoma in {S}outh {A}merica and early-age onset of the disease},
  author = {{P}ineau, {P}. and {R}uiz, {E}. and {D}eharo, {E}ric and {B}ertani, {S}t{\'e}phane},
  editor = {},
  language = {{ENG}},
  abstract = {{H}epatocellular carcinoma ({HCC}) is one of the most predominant tumor types worldwide, being particularly prevalent in sub-{S}aharan {A}frica and {E}ast {A}sia. {H}owever, {HCC} is inexplicably underreported in {S}outh {A}merica, despite unsettling clinical epidemiological trends of the disease on this continent. {H}ere, we review the current knowledge on {HCC} presentation in {P}eru. {W}e emphasize the well-documented occurrence of an early-age nosological form of the disease in {A}ndean descent populations. {W}e further discuss the reasons for such {HCC} clinical presentation, as well as the implications for liver cancer screening, management, and prevention.},
  keywords = {{L}iver cancer ; {C}ancer risk factor ; {H}epatitis {B} virus ({HBV}) ; {I}ndigenous people ; {L}ow- and middle-income countries ; {G}lobal health transition ; {PEROU} ; {ANDES}},
  booktitle = {},
  journal = {{C}linics and {R}esearch in {H}epatology and {G}astroenterology},
  volume = {43},
  numero = {5},
  pages = {522--526},
  ISSN = {2210-7401},
  year = {2019},
  DOI = {10.1016/j.clinre.2018.10.019},
  URL = {https://www.documentation.ird.fr/hor/fdi:010077041},
}

@article{fdi:010075252,
  title = {{E}arly-onset liver cancer in {S}outh {A}merica associates with low hepatitis {B} virus {DNA} burden},
  author = {{M}archio, {A}. and {C}erapio, {J}. {P}. and {R}uiz, {E}. and {C}ano, {L}. and {C}asavilca, {S}. and {T}erris, {B}. and {D}eharo, {E}ric and {D}ejean, {A}. and {B}ertani, {S}t{\'e}phane and {P}ineau, {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{I}n {P}eru, hepatocellular carcinoma ({HCC}) arises in young non-cirrhotic patients. {H}epatitis {B} virus ({HBV}) is suspected to be the prominent etiological agent. {W}e thus performed a comprehensive molecular study of {HBV} infection in 65 {P}eruvian {HCC} patients. {O}nly 51% were considered as persistently infected at the onset. {HBV} {DNA} was found by {PCR} in the tumor and/or matched non-tumor liver tissues in more than 80% of cases (n = 53/65). {HBV} {DNA} was significantly more abundant in livers of younger patients than in those of the older ones. {W}e consistently observed low viral {DNA} burden (0.1-6.5 copies for 100 cells), with viral genomes in younger patients displaying higher proportion of mutations at di-pyrimidines ({T}p{T} and {C}p{C}, {P} = 0.006). {A} drastic activation of multiple {DNA} repair pathways in tumors of younger patients was observed. {O}ur observations clearly challenge the current vision that associates high {HBV} {DNA} load with earlier tumor development. {W}e concluded that in {P}eru, and maybe in other populations with {A}mericas' indigenous ancestry, {HBV}-associated liver tumorigenesis might differ significantly from that generally observed in the rest of the world. {P}rocedures used to screen for {HCC} development in subjects at risk should be adapted to the local situation.},
  keywords = {{PEROU}},
  booktitle = {},
  journal = {{S}cientific {R}eports - {N}ature},
  volume = {8},
  numero = {},
  pages = {art. 12031 [14 p.]},
  ISSN = {2045-2322},
  year = {2018},
  DOI = {10.1038/s41598-018-30229-8},
  URL = {https://www.documentation.ird.fr/hor/fdi:010075252},
}

@article{fdi:010073995,
  title = {{H}epatitis {C} in {L}aos : a 7-year retrospective study on 1765 patients},
  author = {{P}aboriboune, {P}. and {V}ial, {T}homas and {S}itbounlang, {P}. and {B}ertani, {S}t{\'e}phane and {T}repo, {C}. and {D}eny, {P}. and {B}abin, {F}. {X}. and {S}teenkeste, {N}. and {P}ineau, {P}. and {D}eharo, {E}ric},
  editor = {},
  language = {{ENG}},
  abstract = {{H}epatitis {C} virus ({HCV}) is a global health concern, notably in {S}outheast {A}sia, and in {L}aos the presentation of the {HCV}-induced liver disease is poorly known. {O}ur objective was thus to describe a comprehensive {HCV} infection pattern in order to guide national health policies. {A} study on a group of 1765 patients formerly diagnosed by rapid test in health centres was conducted at the {C}entre of {I}nfectiology {L}ao {C}hristophe {M}erieux in {V}ientiane. {T}he demographic information of patients, their infection status (viral load: {VL}), liver function (aminotransferases) and treatments were analysed. {R}esults showed that gender distribution of infected people was balanced; with median ages of 53.8 for men and 51.6years for women (13-86years). {T}he majority of patients (72%) were confirmed positive ({VL}>50{IU}/m{L}) and 28% of them had high {VL} (>6log(10)). {A}bout 23% of patients had level of aminotransferases indicative of liver damage (>40{IU}/m{L}); but less than 20% of patients received treatment. {P}atients rarely received a second sampling or medical imaging. {T}he survey also showed that cycloferon, pegylated interferon and ribavirin were the drugs prescribed preferentially by the medical staff, without following any international recommendations schemes. {I}n conclusion, we recommend that a population screening policy and better management of patients should be urgently implemented in the country, respecting official guidelines. {H}owever, the cost of biological analysis and treatment are significant barriers that must be removed. {P}ublic health resolutions should be immediately enforced in the perspective of meeting the {WHO} {HCV} elimination deadline by 2030.},
  keywords = {{H}epatitis {C} virus ({HCV}) ; {HCV} incidence ; {A}ntiviral agents ; {L}aos ; {LAOS}},
  booktitle = {},
  journal = {{V}irologica {S}inica},
  volume = {33},
  numero = {4},
  pages = {295--303},
  ISSN = {1674-0769},
  year = {2018},
  DOI = {10.1007/s12250-018-0039-9},
  URL = {https://www.documentation.ird.fr/hor/fdi:010073995},
}

@article{fdi:010073707,
  title = {{L}iver clear cell foci and viral infection are associated with non-cirrhotic, non-fibrolamellar hepatocellular carcinoma in young patients from {S}outh {A}merica},
  author = {{C}ano, {L}. and {C}erapio, {J}. {P}. and {R}uiz, {E}. and {M}archio, {A}. and {T}urlin, {B}. and {C}asavilca, {S}. and {T}axa, {L}. and {M}arti, {G}. and {D}eharo, {E}ric and {P}ineau, {P}. and {B}ertani, {S}t{\'e}phane},
  editor = {},
  language = {{ENG}},
  abstract = {{W}e previously described a divergent clinical and molecular presentation of hepatocellular carcinoma ({HCC}) in {P}eru. {T}he present study aimed to further characterize the tissue features associated with this singular nosological form of {HCC} in order to gain insight into the natural history of the disease. {W}e performed an exploratory analysis of the histology of both tumor and non-tumor liver ({NTL}) tissues from 50 {P}eruvian {HCC} patients, and compared with that of 75 individuals with non-{HCC} liver tumor or benign liver lesions as a baseline for {NTL} features. {W}e complemented this approach with a transcriptome analysis in a subset of {NTL} tissue samples and also performed an ultra-sensitive hepatitis {B} virus ({HBV}) detection in liver tissues of the patients. {O}verall, results highlighted the low rate of liver parenchymal alterations in a young patient cohort (median age: 40 years old), despite a strong prevalence of underlying {HBV} infection (c. 67%). {W}ithal, liver clear cell foci of cellular alteration were genuinely associated with {HCC} and appended to some changes in immune and {G} protein-coupled receptor gene expression ontologies. {O}ur findings confirm the occurrence of a particular setting of {HCC} in {S}outh {A}merica, a region where the pathophysiology of liver cancer remains largely unexplored.},
  keywords = {{PEROU}},
  booktitle = {},
  journal = {{S}cientific {R}eports - {N}ature},
  volume = {8},
  numero = {},
  pages = {art. 9945 [12 p.]},
  ISSN = {2045-2322},
  year = {2018},
  DOI = {10.1038/s41598-018-28286-0},
  URL = {https://www.documentation.ird.fr/hor/fdi:010073707},
}

@article{fdi:010073026,
  title = {{N}egative serology of {F}asciola hepatica infection in patients with liver cancer in {P}eru : a preliminary report},
  author = {{M}achicado, {C}. and {B}ertani, {S}t{\'e}phane and {H}errera-{V}elit, {P}. and {E}spinoza, {J}. and {R}uiz, {E}. and {M}arcos, {L}.},
  editor = {},
  language = {{ENG}},
  abstract = {{I}ntroduction: {T}he etiology of several hepatocellular carcinoma ({HCC}) cases remains largely unknown. {A}lthough {F}asciola hepatica has been associated with liver fibrosis in {L}atin {A}merica, it has not yet been associated with {HCC}. {T}his study aimed to determine the existence of specific {I}g{G} antibodies against {F}. hepatica in the serum samples of {HCC} patients. {M}ethods: {I}n total, 13 scrum samples from 13 {HCC} patients were screened using {F}as2-{ELISA}. {R}esults: {F}as2-{ELISA} demonstrated negative results in all {HCC} patients included in this study. {C}onclusions: {T}he pre-existence of {F} hepatica infection in {HCC} patients needs to be further investigated in epidemiological and experimental studies.},
  keywords = {{C}holangiocarcinoma ; {F}asciolosis ; {F}ibrosis ; {H}epatocellular carcinoma ; {L}iver fluke ; {PEROU}},
  booktitle = {},
  journal = {{R}evista da {S}ociedade {B}rasileira de {M}edicina {T}ropical},
  volume = {51},
  numero = {2},
  pages = {231--233},
  ISSN = {0037-8682},
  year = {2018},
  DOI = {10.1590/0037-8682-0180-2017},
  URL = {https://www.documentation.ird.fr/hor/fdi:010073026},
}

@article{fdi:010072740,
  title = {{A} seven-year retrospective study on the surveillance of hepatitis {B} in {L}aos},
  author = {{P}aboriboune, {P}. and {V}ial, {T}homas and {C}hassagne, {F}. and {S}itbounlang, {P}. and {S}oundala, {S}. and {B}ertani, {S}t{\'e}phane and {S}engmanothong, {D}. and {B}abin, {F}. {X}. and {S}teenkeste, {N}. and {D}eny, {P}. and {P}ineau, {P}. and {D}eharo, {E}ric},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjective. {L}ao {PDR} is one of the most highly endemic countries for hepatitis {B} in {A}sia and the second country for liver cancer incidence. {T}herefore, the follow-up of infected individuals through predictive serological markers is of utmost importance to monitor the progression of the pathology and take the decision on treatment. {M}ethods. {A} retrospective-descriptive cohort study was conducted on 3,857 {HBV}-infected patients. {I}nformation about infection status (viral load, {VL}), liver function (aminotransferases), and treatments was recorded. {R}esults. {M}/{F} sex ratio was 1.77 for a median age of 37. {P}atients under 37 displayed higher {VL} than older ones and men had higher {VL} than women. {I}nitial {VL} ranged from <50 {IU}/m{L} to 2.5 10(13) {IU}/m{L}. {M}edian aminotransferase values were 45.5 {U}/{L} for {ALAT} and 44 {U}/{L} for {ASAT}, ranging from <8 to >2,000 {U}/{L}. {M}en had higher aminotransferase than women. {G}lobally 20% of patients received treatment (mainly immunostimulant and reverse-transcriptase inhibitors); 11% had high levels of {VL} and liver enzymes, but only 2% of them were treated. {C}onclusion. {P}ublic health decisions should be taken urgently to rationalise vaccination and provide fair access to early diagnosis and treatment; otherwise the burden of {HBV}-associated diseases will be overwhelming for {L}aos in the near future.},
  keywords = {{LAOS}},
  booktitle = {},
  journal = {{I}nternational {J}ournal of {H}epatology},
  numero = {},
  pages = {art. {ID} 9462475 [11 p.]},
  ISSN = {2090-3448},
  year = {2018},
  DOI = {10.1155/2018/9462475},
  URL = {https://www.documentation.ird.fr/hor/fdi:010072740},
}

@article{fdi:010072370,
  title = {{H}erbal medicine practices of patients with liver cancer in {P}eru : a comprehensive study toward integrative cancer management},
  author = {{R}ojas, {T}. {R}. and {B}ourdy, {G}enevi{\`e}ve and {R}uiz, {E}. and {C}erapio, {J}. {P}. and {P}ineau, {P}. and {G}ardon, {J}acques and {D}oimi, {F}. and {D}eparis, {X}. and {D}eharo, {E}ric and {B}ertani, {S}t{\'e}phane},
  editor = {},
  language = {{ENG}},
  abstract = {{R}ationale: {T}he highest burden of liver cancer occurs in developing countries, where the use of herbal medicine ({HM}) is still widespread. {D}espite this trend, few studies have been conducted to report {HM} practices of patients with a hepatic tumor in the developing world. {H}ence, this study aimed to document the use of {HM} among patients with liver cancer in {P}eru. {S}tudy {D}esign and {M}ethods: {A} comparative behavioral epidemiological survey was conducted among liver cancer patients attending the {N}ational {C}ancer {I}nstitute of {P}eru. {I}nformation was obtained by direct interviews based on a semistructured questionnaire. {T}he use of {HM} in {P}eruvian liver cancer patients was reported, first, regarding general consumption prior to the onset of disease, and second, after the appearance of symptoms that patients would relate to their tumor. {I}n parallel, general consumption of {HM} in noncancerous people was assessed as a comparative figure. {A} correspondence analysis was performed to reveal potential associations between the symptoms of cancer and the specific use of {HM}. {R}esults: {E}ighty-eight patients and 117 noncancerous individuals participated in the survey. {O}verall, 68.3% of the people interviewed claimed to use {HM} on a regular basis for general health preservation. {F}urthermore, 56.8% of the patients turned to plants first to treat the disorders for which they later came to the cancer care center. {W}hen compared with the number of plant species used routinely (n = 78), a selection of plants was made by patients in response to the symptoms of cancer (n = 46). {A}t least 2 plant species, {A}loe vera and {M}orinda citrifolia, were significantly associated with the treatment of liver cancer-related symptoms in the patient group. {C}onclusions: {T}he present study is the first survey on the {HM} practices of patients with liver cancer in {L}atin {A}merica and, more broadly, in the developing world. {O}ur findings confirm that {HM} remains one of the principal primary health care resources in {P}eru, even for a severe disease like liver cancer. {T}hese traditional, complementary and alternative medicine practices should be taken into consideration in {P}eruvian health programs aiming to educate the population in cancer prevention and treatment, as well as integrative cancer management.},
  keywords = {behavioral epidemiological survey ; cancer ; complementary and alternative medicine ; developing world ; ethnobotany ; {I}ndigenous people ; integrative medicine ; {L}atin {A}merica ; liver disease ; traditional medicine ; {PEROU}},
  booktitle = {},
  journal = {{I}ntegrative {C}ancer {T}herapies},
  volume = {17},
  numero = {1},
  pages = {52--64},
  ISSN = {1534-7354},
  year = {2018},
  DOI = {10.1177/1534735416681642},
  URL = {https://www.documentation.ird.fr/hor/fdi:010072370},
}

@article{fdi:010070745,
  title = {{H}epatocellular carcinoma surgery outcomes in the developing world : a 20-year retrospective cohort study at the {N}ational {C}ancer {I}nstitute of {P}eru},
  author = {{R}uiz, {E}. and {R}ojas {R}ojas, {T}. and {B}errospi, {F}. and {C}hávez, {I}. and {L}uque, {C}. and {C}ano, {L}. and {D}oimi, {F}. and {P}ineau, {P}. and {D}eharo, {E}ric and {B}ertani, {S}t{\'e}phane},
  editor = {},
  language = {{ENG}},
  abstract = {},
  keywords = {{PEROU}},
  booktitle = {},
  journal = {{H}eliyon},
  volume = {2},
  numero = {1},
  pages = {art. e00052 [19  en ligne]},
  ISSN = {2405-8440},
  year = {2016},
  DOI = {10.1016/j.heliyon.2015.e00052},
  URL = {https://www.documentation.ird.fr/hor/fdi:010070745},
}

@article{fdi:010067735,
  title = {{A} 13-year retrospective study on primary liver cancer in {C}ambodia : a strikingly high hepatitis {C} occurrence among hepatocellular carcinoma cases},
  author = {{C}hassagne, {F}. and {R}ojas, {T}. {R}. and {B}ertani, {S}t{\'e}phane and {B}ourdy, {G}enevi{\`e}ve and {E}av, {S}. and {R}uiz, {E}. and {P}ineau, {P}. and {D}eharo, {E}ric},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjectives: {H}epatocellular carcinoma ({HCC}) is the main type of primary liver cancer ({PLC}) worldwide, but cholangio-carcinoma ({CCA}) may be predominant in some specific regions of {S}outheast {A}sia. {T}he aim of the present study was to delineate a pattern of {C}ambodian {PLC} patients attending the {C}almette {H}ospital in the {C}ambodian capital {P}hnom {P}enh. {M}aterials and {M}ethods: {A} total of 553 medical charts diagnosing {PLC}s from {J}anuary 2003 to {M}ay 2015 were obtained from both the {O}ncology and {H}epato-{G}astroenterology {D}epartments of the {C}almette {H}ospital. {R}esults: {HCC} was the predominant type of {PLC} recorded, with 511 cases (92.4%), whereas {CCA} represented merely 7.6% (42 cases) of the overall series. {H}epatitis {B} virus ({HBV}; 44.3%) and hepatitis {C} virus ({HCV}; 43%) infection rates were similar among the {HCC} patients, while small subsets of {CCA} patients were infected with {HBV} (15.4%) or {HCV} (11.5%). {M}ost {HCC} (84%) and {CCA} (73.8%) patients received palliative treatment only. {C}onclusion: {T}he present study indicates that {HCC} is the main form of primary hepatic neoplasm among {PLC} patients attending a hospital in {C}ambodia. {HBV} and {HCV} infections represented equivalent burdens and major contributing factors to {HCC}. {T}herefore, the implementation of prevention programs for these infectious agents should become a priority for health policy makers in the country.},
  keywords = {{H}epatocellular carcinoma ; {C}holangiocarcinoma ; {H}epatitis {B} virus ; {H}epatitis {C} virus ; {O}pisthorchis viverrini ; {C}ambodia ; {CAMBODGE}},
  booktitle = {},
  journal = {{O}ncology},
  volume = {91},
  numero = {2},
  pages = {106--116},
  ISSN = {0030-2414},
  year = {2016},
  DOI = {10.1159/000446398},
  URL = {https://www.documentation.ird.fr/hor/fdi:010067735},
}

@article{fdi:010063661,
  title = {{A} peculiar mutation spectrum emerging from young {P}eruvian patients with hepatocellular carcinoma},
  author = {{M}archio, {A}. and {B}ertani, {S}t{\'e}phane and {R}ojas, {T}. {R}. and {D}oimi, {F}. and {T}erris, {B}. and {D}eharo, {E}ric and {D}ejean, {A}. and {R}uiz, {E}. and {P}ineau, {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{H}epatocellular carcinoma usually afflicts individuals in their later years following longstanding liver disease. {I}n {P}eru, hepatocellular carcinoma exists in a unique clinical presentation, which affects patients around age 25 with a normal, healthy liver. {I}n order to deepen our understanding of the molecular processes ongoing in {P}eruvian liver tumors, mutation spectrum analysis was carried out on hepatocellular carcinomas from 80 {P}eruvian patients. {S}equencing analysis focused on nine genes typically altered during liver carcinogenesis, i.e. {ARID}2, {AXIN}1, {BRAF}, {CTNNB}1, {NFE}2{L}2, {H}/{K}/{N}-{RAS}, and {TP}53. {W}e also assessed the transcription level of factors involved in the control of the alpha-fetoprotein expression and the {H}ippo signaling pathway that controls contact inhibition in metazoans. {T}he mutation spectrum of {P}eruvian patients was unique with a major class of alterations represented by {I}nsertions/{D}eletions. {T}here were no changes at hepatocellular carcinoma-associated mutation hotspots in more than half of the specimens analyzed. {F}urthermore, our findings support the theory of a consistent collapse in the {H}ippo axis, as well as an expression of the stemness factor {NANOG} in high alpha-fetoprotein-expressing hepatocellular carcinomas. {T}hese results confirm the specificity of {P}eruvian hepatocellular carcinoma at the molecular genetic level. {T}he present study emphasizes the necessity to widen cancer research to include historically neglected patients from {S}outh {A}merica, and more broadly the {G}lobal {S}outh, where cancer genetics and tumor presentation are divergent from canonical neoplasms.},
  keywords = {{PEROU}},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {9},
  numero = {12},
  pages = {e114912 [24 ]},
  ISSN = {1932-6203},
  year = {2014},
  DOI = {10.1371/journal.pone.0114912},
  URL = {https://www.documentation.ird.fr/hor/fdi:010063661},
}

@article{fdi:010061732,
  title = {{L}a simalikalactone {E}, mol{\'e}cule antipaludique et anticancer = {S}imalikalactone {E}, anti-malarial and anticancer molecule},
  author = {{D}eharo, {E}ric and {J}ullian, {V}al{\'e}rie and {B}ertani, {S}t{\'e}phane and {B}ourdy, {G}enevi{\`e}ve},
  editor = {},
  language = {{FRE}},
  abstract = {{E}n octobre dernier, le {P}rix 2013 de l’innovation pour le {S}ud d{\'e}cern{\'e} par l’{I}nstitut de recherche pour le d{\'e}veloppement ({IRD}) r{\'e}compensait la d{\'e}couverte d’une mol{\'e}cule aux propri{\'e}t{\'e}s miraculeuses : la simalikalactone {E}. {I}sol{\'e} de {Q}uassia amara, une plante m{\'e}dicinale amazonienne, cette mol{\'e}cule est {\`a} la fois un antipaludique et un anticancer. {C}ette d{\'e}couverte permettra-t-elle {\`a} la plante d’acc{\'e}der au statut des grandes plantes m{\'e}dicaments qui ont boulevers{\'e} la th{\'e}rapeutique en sauvant des milliers de vies ? {C}’est l’espoir nourri par les chercheurs. {H}istoire d’une d{\'e}couverte.},
  keywords = {{AMAZONIE}},
  booktitle = {},
  journal = {{B}iofutur},
  numero = {350},
  pages = {56--59},
  ISSN = {0294-3506},
  year = {2014},
  URL = {https://www.documentation.ird.fr/hor/fdi:010061732},
}

@article{fdi:010060508,
  title = {{A}n atypical age-specific pattern of hepatocellular carcinoma in {P}eru : a threat for {A}ndean populations},
  author = {{B}ertani, {S}t{\'e}phane and {P}ineau, {P}. and {L}oli, {S}. and {M}oura, {J}ulien and {Z}imic, {M}. and {D}eharo, {E}ric and {R}uiz, {E}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {I}n {S}outh {A}merica, the highest incidence of primary liver cancer is observed in {P}eru. {H}owever, national estimations on hepatocellular carcinoma incidence and mortality are approximated using aggregated data from surrounding countries. {T}hus, there is a lack of tangible information from {P}eru that impairs an accurate description of the local incidence, presentation, and outcomes of hepatocellular carcinoma. {T}he present study attempts to fill this gap and assesses the clinical epidemiology of hepatocellular carcinoma in this country. {M}ethods: {A} retrospective cohort study was conducted by analysing the medical charts of 1,541 patients with hepatocellular carcinoma admitted between 1997 and 2010 at the {P}eruvian national institute for cancer. {T}he medical records including liver function, serologic status, and tumor pathology and stage were monitored. {S}tatistical analyses were performed in order to characterize tumor presentation according to demographic features, risk factors, and regional origin. {R}esults: {S}urprisingly, the age distribution of the patient population displayed bimodality corresponding to two distinct age-based subpopulations. {W}hile an older group was in keeping with the age range observed for hepatocellular carcinoma around the world, a younger population displayed an abnormally juvenile mean age of 25.5 years old. {I}n addition, each subpopulation displayed age-specific pathophysiological and clinical characteristics. {C}onclusions: {T}he analysis suggests two different age-specific natural histories of hepatocellular carcinoma in the {P}eruvian patient population. {T}his otherwise unusual tumor process that is ongoing in younger patients leads to the hypothesis that there may be a {P}eru-endemic risk factor driving hepatocarcinogenesis in the local population.},
  keywords = {{PEROU} ; {ANDES}},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {8},
  numero = {6},
  pages = {e67756},
  ISSN = {1932-6203},
  year = {2013},
  DOI = {10.1371/journal.pone.0067756},
  URL = {https://www.documentation.ird.fr/hor/fdi:010060508},
}

@article{fdi:010057237,
  title = {{T}he in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine},
  author = {{G}aravito, {G}. and {B}ertani, {S}t{\'e}phane and {Q}uiliano, {M}. and {V}alentin, {A}. and {A}ldana, {I}. and {D}eharo, {E}ric},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he effectiveness of methylene blue ({MB}) combined with pyrimethamine ({PYR}), chloroquine ({CQ}) or quinine ({Q}) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, {P}lasmodium berghei. {A} marked potentiation was observed when {MB} was administered at a non-curative dose of 15 mg/kg/day in combination with {PYR} (0.19 mg/kg/day) or {Q} (25 mg/kg/day). {N}o synergy was found between {MB} (15 mg/{K}g) and {CQ} (0.75 mg/{K}g). {O}ur results suggest that the combination of {MB} with {PYR} or {Q} may improve the efficacy of these currently used antimalarial drugs.},
  keywords = {antimalarials ; methylene blue ; drug combination},
  booktitle = {},
  journal = {{M}emorias do {I}nstituto {O}swaldo {C}ruz},
  volume = {107},
  numero = {6},
  pages = {820--823},
  ISSN = {0074-0276},
  year = {2012},
  URL = {https://www.documentation.ird.fr/hor/fdi:010057237},
}

@article{fdi:010055854,
  title = {{N}ew findings on {S}imalikalactone {D}, an antimalarial compound from {Q}uassia amara {L}. ({S}imaroubaceae)},
  author = {{B}ertani, {S}t{\'e}phane and {H}ouel, {E}. and {J}ullian, {V}al{\'e}rie and {B}ourdy, {G}enevi{\`e}ve and {V}alentin, {A}. and {S}tien, {D}. and {D}eharo, {E}ric},
  editor = {},
  language = {{ENG}},
  abstract = {{Q}uassia amara {L} ({S}imaroubaceae) is a species widely used as tonic and is claimed to be an efficient antimalarial all over the {N}orthern part of the {A}mazon basin. {Q}uassinoid compound {S}imalikalactone {D} ({S}k{D}) has been shown to be one of the molecules responsible for the antiplasmodial activity of a watery preparation made out of juvenile fresh leaves of this plant. {B}ecause of its strong antimalarial activity, we decided to have a further insight of {S}k{D} pharmacological properties, alone or in association with classical antimalarials. {A}t concentrations of up to 200 mu {M}, we showed herein that {S}k{D} did not exert any apoptotic or necrotic activities in vitro on lymphoblastic cells. {H}owever, an antiproliferative effect was evident at concentrations higher than 45 n{M}. {S}k{D} was inefficient at inhibiting heme biomineralization and the new permeability pathways induced by the parasite in the host erythrocyte membrane. {W}ith respect to {P}lasmodium falciparum erythrocytic stages, {S}k{D} was almost inactive on earlier and later parasite stages, but potently active at the 30th h of parasite cycle when {DNA} replicates in mature trophozoites. {I}n vitro combination studies with conventional antimalarial drugs showed that {S}k{D} synergizes with atovaquone ({ATO}). {T}he activity of {ATO} on the {P}lasmodium mitochondrial membrane potential was enhanced by {S}k{D}, which on its own had a poor effect on this cellular parameter.},
  keywords = {{A}ntimalarial ; {S}imalikalactone {D} ; {Q}uassinoid ; {P}lasmodium ; {Q}uassia amara ; {PEROU}},
  booktitle = {},
  journal = {{E}xperimental {P}arasitology},
  volume = {130},
  numero = {4},
  pages = {341--347},
  ISSN = {0014-4894},
  year = {2012},
  DOI = {10.1016/j.exppara.2012.02.013},
  URL = {https://www.documentation.ird.fr/hor/fdi:010055854},
}