@article{fdi:35969,
  title = {{S}usceptibility of {P}lasmodium falciparum strains to mefloquine in an urban area in {S}enegal},
  author = {{H}atin, {I}. and {T}rape, {J}ean-{F}ran{\c{c}}ois and {L}egros, {F}abrice and {B}auchet, {J}. and {L}e {B}ras, {J}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A} total of 47 nonimmune febrile patients from {P}ikine, {S}enegal, with greater than 1,000 {P}lasmodium falciparum asexual forms per microliter whole blood were given 12.5 mg per kg body weight of mefloquine in a single oral dose and were followed up daily until day 7 and also on day 14 of the study. {S}even of the patients who vomited, four who had 4-aminoquinolines in their blood, and five dropouts were excluded. {F}ever and parasitaemia were suppressed within four days until day fourteen in 29 of the 31 remaining patients, including 10 with {P}. falciparum strains that had a low sensitivity to mefloquine. {T}wo failures were due to poor absorption of mefloquine. {T}he presence of {P}. falciparum strains with low in vitro susceptibility to mefloquine did not affect, within 14 days, the clinical and parasitological efficacy of a single oral dose mefloquine regimen in patients who had received no previous antimalarial treatment and who did not have partial immune protection.},
  keywords = {{PALUDISME} ; {TRAITEMENT} {MEDICAL} ; {EFFICACITE} ; {SENSIBILITE} {RESISTANCE} ; {AGENT} {PATHOGENE} ; {ZONE} {PERIURBAINE} ; {EVALUATION} {IN} {VIVO} ; {MEFLOQUINE} ; {CHLOROQUINE} ; {HALOFANTRINE} ; {SENEGAL} ; {DAKAR} ; {PIKINE}},
  booktitle = {},
  journal = {{B}ulletin de l'{O}rganisation {M}ondiale de la {S}ant{\'e}},
  volume = {70},
  numero = {3},
  pages = {363--367},
  ISSN = {0043-9686},
  year = {1992},
  URL = {https://www.documentation.ird.fr/hor/fdi:35969},
}