@article{fdi:010097015,
  title = {{A} gut microbiome-kidney-heart axis predictive of future cardiovascular diseases},
  author = {{C}hechi, {K}. and {C}hakaroun, {R}. and {M}yridakis, {A}. and {F}orslund-{S}tartceva, {S}. {K}. and {F}romentin, {S}. and {N}ielsen, {T}. and {A}ron-{W}isneswky, {J}. and {B}elda, {E}. and {P}rifti, {E}di and {L}assen, {P}. {B}. and {F}alony, {G}. and {V}ieira-{S}ilva, {S}. and {C}hilloux, {J}. and {S}onomura, {K}. and {H}oyles, {L}. and {M}artinez-{G}ili, {L}. and {P}allotti, {F}. and {A}ndrikopoulos, {P}. and {P}uig-{C}astellví, {F}. and {T}apia, {R}. {P}. and {C}astro-{D}ionicio, {I}. and {R}oume, {H}. and {P}ons, {N}. and {L}e {C}hatelier, {E}. and {Q}uinquis, {B}. and {G}alleron, {N}. and {B}erland, {M}. and {O}lanipekun, {M}. {T}. and {J}ia, {M}. {Y}. and {M}anolias, {A}. and {H}olmes, {B}. and {A}driouch, {S}. and {B}lüher, {M}. and {C}oelho, {L}. {P}. and {D}a {S}ilva, {K}. and {G}alan, {P}. and {J}i, {B}. {Y}. and {N}eves, {A}. {L}. and {R}ouault, {C}. and {S}alem, {J}. {E}. and {T}remaroli, {V}. and {H}ansen, {T}. {H}. and {S}ondertoft, {N}. {B}. and {L}ewinter, {C}. and {P}edersen, {H}. {K}. and {M}ark, {P}. {D}. and {G}oetze, {J}. {P}. and {K}ober, {L}. and {V}estergaard, {H}. and {H}ansen, {T}. and {Z}ucker, {J}ean-{D}aniel and {S}ato, {T}. {A}. and {H}ercberg, {S}. and {B}äckhed, {F}. and {L}etunic, {I}. and {O}ppert, {J}. {M}. and {N}ielsen, {J}. and {R}aes, {J}. and {T}zoulaki, {I}. and {D}ehghan, {A}. and {Z}uber, {V}. and {B}ouzigon, {E}. and {L}athrop, {M}. and {R}aina, {P}. and {F}roguel, {P}. and {M}atsuda, {F}. and {D}emenais, {F}. and {G}auguier, {D}. and {S}tumvoll, {M}. and {B}ork, {P}. and {P}edersen, {O}. and {E}hrlich, {S}. {D}. and {C}l{\'e}ment, {K}. and {D}umas, {M}. {E}. and {M}eta{C}ardis {C}onsortium,},
  editor = {},
  language = {{ENG}},
  abstract = {{C}ardiovascular diseases ({CVD}) remain a major global health challenge. {E}arly markers of disease initiation and progression are urgently needed. {W}e, and others, have previously shown changes in the gut microbiome in association with metabolic and {CVD}. {H}ere, we demonstrate that gut microbiome-related changes can be detected in association with subclinical variations in heart and kidney function. {M}arkers related to gut microbial metabolism of aromatic amino acids, phenylalanine and tyrosine, associate with circulating pro-atrial natriuretic peptide and estimated glomerular filtration rate in a metabolically healthy {E}uropean population. {O}bservational and genetic evidence further identify microbiome-related metabolites as mediators of this gut microbiome-kidney axis, with their baseline levels associating with incident {CVD} in an external {C}anadian population. {A}ltogether, our work suggests that the gut microbiome interacts with the cardiorenal axis and participates in an interorgan crosstalk affecting host physiology and risk of {CVD}.},
  keywords = {{EUROPE} ; {CANADA}},
  booktitle = {},
  journal = {{N}ature {C}ommunications},
  volume = {17},
  numero = {1},
  pages = {3477 [21 p.]},
  year = {2026},
  DOI = {10.1038/s41467-026-69405-0},
  URL = {https://www.documentation.ird.fr/hor/fdi:010097015},
}