@article{fdi:010096974,
  title = {{I}mpact of intensive control on malaria population genomics under elimination settings in {S}outheast {A}sia},
  author = {{L}i, {X}. and {A}rya, {G}. {A}. and {T}hu, {A}. {M}. and {L}andier, {J}ordi and {P}arker, {D}. {M}. and {D}elmas, {G}. and {R}eyes, {A}. and {L}win, {K}. {M}. and {S}riprawat, {K}. and {N}osten, {F}. and {A}nderson, {T}. {J}. {C}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he malaria elimination programme in {K}ayin {S}tate ({M}yanmar) uses malaria posts for rapid detection and treatment, together with mass drug administration in high-transmission villages, which has reduced transmission by 97%. {H}ere we examine the impact of control on parasite genomic parameters to inform future control efforts. {U}sing 2,270 genome-sequenced {P}lasmodium falciparum infections from 283 malaria posts, sampled over 58 months (2015-2020), we find that parasite effective population size decreased over the study period, but there was minimal change in artemisinin resistance allele frequency until 2020, when just one predominant genotype (carrying kelch13-{R}561{H}) remained. {W}e observed sustained localized transmission of unique parasite genotypes revealing transmission chains and positive correlations in parasite relatedness for <= 20 km. {M}ass drug administration resulted in parasite founder effects, providing genomic evidence for the efficacy of this control tool. {T}hese results reveal changes in population structure driven by control and rapid shifts in allele frequency in a parasite population close to elimination.},
  keywords = {{MYANMAR} ; {ASIE} {DU} {SUD} {EST}},
  booktitle = {},
  journal = {{N}ature {M}icrobiology},
  volume = {[{E}arly access]},
  numero = {},
  pages = {[27 p.]},
  ISSN = {2058-5276},
  year = {2026},
  DOI = {10.1038/s41564-026-02327-1},
  URL = {https://www.documentation.ird.fr/hor/fdi:010096974},
}