%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture non répertoriées par l'AERES
%A Honles, J.
%A Cerapio, J.P.
%A Monge, C.
%A Marchio, A.
%A Ruiz, E.
%A Fernández, R.
%A Casavilca-Zambrano, S.
%A Contreras-Mancilla, J.
%A Vidaurre, T.
%A Condom, Thomas
%A Zerathe, Swann
%A Dangles, Olivier
%A Deharo, Eric
%A Herrera, Javier
%A Pineau, P.
%A Bertani, Stéphane
%T Mapping pesticide mixtures to cancer risk at the country scale with spatial exposomics
%D 2026
%L fdi:010096760
%G ENG
%J Nature Health
%@ 3005-0693
%K PEROU
%P [25 ]
%R 10.1038/s44360-026-00087-0
%U https://www.documentation.ird.fr/hor/fdi:010096760
%V [Early access]
%W Horizon (IRD)
%X Despite decades of concern over the carcinogenic potential of agricultural pesticides, toxicological studies relying on single endpoints have yet to establish a definitive link between environmental pesticide exposure and cancer in real-world contexts. Here we use an integrative spatial Bayesian framework that merges high-resolution environmental pesticide risk modelling with comprehensive cancer registry data to map pesticide-linked cancer clusters in Peru with unprecedented precision. Our process-based model, encompassing 31 key pesticide active ingredients, together with an innovative stratification of cancer cases by developmental lineage, reveals a robust spatial association between environmental pesticide exposure risk and cancer incidence. In pesticide-associated cancer hotspots, exposomic profiling of liver tissue?a primary target of chemical carcinogens?uncovers a distinct transcriptomic signature of pesticide exposure, implicating a non-genotoxic mode of action that disrupts core regulatory circuitries sustaining cell identity. Collectively, these findings strongly support a mechanistic link between pesticide exposure and cancer, challenging assumptions of human non-carcinogenicity derived from reductionist experimental models. This study redefines the exposome as a lineage-conditioned, mechanistically tractable framework and shows how complex pesticide mixtures can contribute to carcinogenic trajectories, with profound and far-reaching implications for global health policy and socio-ecological equity.
%$ 050MEDECI ; 021ENVECO ; 076RAVPLA07