Danfakha M. auteur aut IRD Diallo M.A. auteur aut IRD Boh O.M. auteur aut IRD Ba M.F. auteur aut IRD Seck R.N. auteur aut IRD Faye C. auteur aut IRD Ridde Valéry auteur aut IRD text journalArticle eng text/pdf reformatted digital access Introduction: rabies remains a major public health issue in Senegal, with Saint-Louis being one of the most affected regions in 2022. Diagnostic challenges, gaps in case management, and inadequate attitudes and practices among health providers and the population contribute to the increasing risk. This study aimed to assess the knowledge, attitudes, and practices (KAP) of human and animal health providers regarding rabies in the Saint-Louis district. Methods: data were collected using a questionnaire developed on KoboToolbox and analyzed using R software version 4.3.3. This was a cross-sectional and analytical study conducted from July 15 to 28, 2024, with a sample of 161 human and animal health providers. The analyses included descriptive, bivariate, and multivariate assessments of variables, taking into account group comparisons. Results: two out of five participants (41.0%) had sufficient knowledge about rabies, 38.5% demonstrated a positive attitude, while 31.1% adopted good practices in the event of an animal bite. Multivariate analysis revealed that animal health providers were 7.64 times more likely to have sufficient knowledge about rabies compared to their human health counterparts (p = 0.083). Human and animal health providers with sufficient knowledge were 3.41 times more likely to adopt a positive attitude towards rabies (95% CI: [1.01-12.70]). Additionally, human and animal health providers with a positive attitude were 3.23 times more likely to implement good practices in response to an animal bite (95% CI: [1.08-10.70]). Conclusion: the study highlights the need to strengthen the training of human and animal health providers on rabies, emphasizing a "One Health" approach. Enhancing knowledge appears to be a critical lever for positively influencing attitudes and practices, thereby contributing to better management of this zoonosis. specialized SENEGAL SAINT LOUIS 050 056 18 10 en ligne [19 ] 2025 2707-2800 https://www.documentation.ird.fr/hor/fdi:010096105 10.11604/pamj-oh.2025.18.10.46523 2707-2800 [F B010096105] https://www.documentation.ird.fr/hor/fdi:010096105 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2026-01/010096105.pdf IRD - Base Horizon / Pleins textes 2025-12-12 2026-06-12 fdi:010096105 fre