@article{fdi:010095934,
  title = {{P}rominent mediatory role of gut microbiome in the effect of lifestyle on host metabolic phenotypes},
  author = {{A}driouch, {S}. and {B}elda, {E}. and {S}wartz, {T}. {D}. and {F}orslund, {S}. and {P}rifti, {E}di and {A}ron-{W}isnewsky, {J}. and {C}hakaroun, {R}. and {N}ielsen, {T}. and {P}oitou, {C}. and {B}el-{L}assen, {P}. and {R}ouault, {C}. and {L}e {R}oy, {T}. and {A}ndrikopoulos, {P}. and {C}hechi, {K}. and {P}uig-{C}astellví, {F}. and {D}ionicio, {I}. {C}. and {F}roguel, {P}. and {H}olmes, {B}. and {A}lili, {R}. and {A}ndreelli, {F}. and {S}oula, {H}. and {S}alem, {J}. {E}. and {F}alony, {G}. and {V}ieira-{S}ilva, {S}. and {R}aes, {J}. and {B}ork, {P}. and {S}tumvoll, {M}. and {P}edersen, {O}. and {E}hrlich, {S}. {D}. and {D}umas, {M}. {E}. and {O}ppert, {J}. {M}. and {D}ao, {M}. {C}. and {Z}ucker, {J}ean-{D}aniel and {C}l{\'e}ment, {K}.},
  editor = {},
  language = {{ENG}},
  abstract = {{L}ifestyle factors influence both gut microbiome composition and host metabolism, yet their combined and mediating effects on host phenotypes remain poorly characterized in cardiometabolic populations. {I}n 1,643 participants from the {M}eta{C}ardis study, we developed a composite lifestyle score ({QASD}: dietary quality, physical activity, smoking, and diet diversity) that outperformed individual lifestyle variables in explaining microbial gene richness and exhibited a significant impact on the gut microbiome composition. {W}hile bidirectional pathways linking the {QASD} score, host phenotypes, and microbiome composition were assessed, causal inference-based mediation analyses indicated stronger effects when the microbiome was modeled as the mediator variable, particularly in relation to the insulin resistance-associated profile. {M}icrobiome gene richness emerged as a key mediator explaining 27.8% of {QASD} score's effect on the insulin resistance marker ({HOMA}-{IR}), while no significant mediation was observed on {BMI}. {E}xtended mediation analyses on microbial species and serum metabolomics deconfounded for drug use and clinical profiles identified 47 mediations where microbial taxa mediated more than 20% of the effect of the {QASD} score on serum metabolites associated with insulin resistance. {N}otably, several {F}aecalibacterium lineages enriched in individuals with high {QASD} score played a significant mediatory role in increasing the serum biomarkers of microbiome diversity (as cinnamoylglycine or 3-phenylpropionate). {C}onversely, elevated levels of secondary bile acids in individuals with low {QASD} scores were strongly mediated by high levels of {C}lostridium bolteae. {T}hese findings highlight distinct and clinically relevant microbiome pathways linking lifestyle behaviors to cardiometabolic risks.{O}ne sentence summary:{T}he gut microbiome mediates the impact of diet quality and diversity, physical activity and smoking status - combined in a composite lifestyle score - on cardiometabolic phenotypes.},
  keywords = {{G}ut microbiome ; nutrition ; lifestyle ; mediation ; {EUROPE}},
  booktitle = {},
  journal = {{G}ut {M}icrobes},
  volume = {17},
  numero = {1},
  pages = {2599565 [34 p.]},
  ISSN = {1949-0976},
  year = {2025},
  DOI = {10.1080/19490976.2025.2599565},
  URL = {https://www.documentation.ird.fr/hor/fdi:010095934},
}