%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Bonguili, N. C. B.
%A Mombo, I. M.
%A Lenguiya, L. H.
%A Lattaphasavang, V.
%A Pabouriboune, P.
%A Deharo, Eric
%A Fritz, M.
%A Lyelet, J. E. D.
%A Elguero, Eric
%A Koukouikila-Koussounda, F.
%A Mayengue, P. I.
%A Leroy, Eric
%A Niama, R. F.
%A Locatelli, Sabrina
%T Etiology and epidemiology of respiratory infections in community-based influenza-like illness during the COVID-19 pandemic, Vientiane, Lao People's Democratic Republic
%D 2025
%L fdi:010095493
%G ENG
%J International Journal of Infectious Diseases
%@ 1201-9712
%K Respiratory infections ; Influenza-like illness ; Co-infections ; SARS-CoV-2 ; Community surveillance ; Lao PDR
%K LAOS
%K VENTIANE
%M ISI:001602507700001
%P 108079 [8 ]
%R 10.1016/j.ijid.2025.108079
%U https://www.documentation.ird.fr/hor/fdi:010095493
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2025-12/010095493.pdf
%V 161
%W Horizon (IRD)
%X Objectives: Respiratory infections pose an ongoing global public health burden, with multiple viral and bacterial etiologies. This study aimed to characterize the etiology of influenza-like illness (ILI) during the COVID-19 pandemic in a community cohort in Vientiane, Lao People's Democratic Republic (Lao PDR). Methods: From September 2021 to April 2022, 6300 individuals from 999 households in 25 villages were enrolled in a prospective surveillance study. Oropharyngeal swabs were collected from ILI cases and tested for SARS-CoV-2 using reverse transcription-polymerase chain reaction, and for 21 additional respiratory pathogens using a multiplex panel. Results: Among 462 samples analyzed, 360 (77.92%) were positive for at least one pathogen, including 338 viral and 79 bacterial infections. SARS-CoV-2 was predominant (67.53%), followed by Staphylococcus aureus (12.55%), human rhinovirus (6.93%), and Streptococcus pneumoniae (5.41%). Seasonal viruses, such as influenza A/B, respiratory syncytial virus, human parainfluenza virus, and human metapneumovirus were notably absent. Co-infections occurred in 21.21% of cases, with lower rates among SARS-CoV-2-positive individuals. Conclusions: These findings highlight the dominance of SARS-CoV-2 and the suppression of typical seasonal viruses, likely due to public health measures and viral interference. The results emphasize the importance of multiplex, community-level surveillance to understand respiratory pathogen dynamics and to strengthen preparedness in resource-limited settings.
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