@article{fdi:010095321,
  title = {{T}racking down the origin and subsequent spread of {SARS}-{C}o{V}-2 lineage b.1.619},
  author = {{B}ollen, {N}. and {H}ong, {S}. {L}. and {P}otter, {B}. and {L}ienhard, {R}. and {T}ritten, {M}. {L}. and {S}ierro, {N}. and {G}uedj, {E}. and {D}ulize, {R}. and {B}ornand, {D}. and {A}uberson, {M}. and {B}erthouzoz, {M}. and {D}uvoisin, {P}. and {I}vanov, {N}. and {P}eitsch, {M}. {C}. and {H}ill, {V}. and {M}atheeussen, {V}. and {B}ontems, {S}. and {V}erhasselt, {B}. and {D}egosserie, {J}. and {W}aumans, {L}. and {B}ayon-{V}icente, {G}. and {R}eynders, {M}. and {C}attoir, {L}. and {C}oste, {V}. and {V}algaeren, {H}. and {V}an {W}eyenbergh, {J}. and {C}uypers, {L}. and {A}ndre, {E}. and {D}urkin, {K}. and {M}aes, {P}. and {K}han, {K}. and {H}uber, {C}. and {S}uchard, {M}. {A}. and {F}oudi, {M}. {M}. and {G}odwe, {C}. and {Y}ifomnjou, {M}. {H}. {M}. and {L}andry, {M}. and {N}jouom, {R}. and {K}ingebeni, {P}. {M}. and {O}luniyi, {P}. and {O}lawoye, {I}. {B}. and {H}appi, {C}. and {A}youba, {A}hidjo and {P}eeters, {M}artine and {B}ehillil, {S}. and {S}imon-{L}ori{\`e}re, {E}. and {H}{\¨o}lzer, {M}. and {D}ellicour, {S}. and {D}udas, {G}. and {B}aele, {G}.},
  editor = {},
  language = {{ENG}},
  abstract = {{S}ince late 2020, the emergence of variants of concern ({VOC}s) of {SARS}-{C}o{V}-2 has been of concern to public health, researchers and policymakers. {M}utations in the {SARS}-{C}o{V}-2 genome-for which clear evidence is available indicating a significant impact on transmissibility, severity and/or immunity-illustrate the importance of genomic surveillance and monitoring the evolution and geographic spread of novel lineages. {L}ineage {B}.1.619 was first detected in {S}witzerland in {J}anuary 2021, in international travellers returning from {C}ameroon. {T}his lineage was subsequently also detected in {R}wanda, {B}elgium, {C}ameroon, {F}rance, and many other countries and is characterised by spike protein amino acid mutations {N}440{K} and {E}484{K} in the receptor binding domain, which are associated with immune escape and higher infectiousness. {I}n this study, we perform a phylogeographic analysis to track the geographic origin and subsequent dispersal of {SARS}-{C}o{V}-2 lineage {B}.1.619. {W}e employ a recently developed travel history-aware phylogeographic model, enabling us to incorporate genomic sequences with associated travel information. {W}e estimate that {B}.1.619 most likely originated in {C}ameroon, in {N}ovember 2020. {W}e estimate the influence of the number of air-traffic passengers on the dispersal of {B}.1.619 but find no significant effect, illustrative of the complex dispersal patterns of {SARS}-{C}o{V}-2 lineages. {F}inally, we examine the metadata associated with infected {B}elgian patients and report a wide range of symptoms and medical interventions.},
  keywords = {{SARS}-{C}o{V}-2 ; {COVID}-19 ; {B}.1.619 ; phylogenetics ; phylogeography ; {GLM} ; air ; traffic ; {B}ayesian inference ; {M}arkov chain {M}onte {C}arlo ; {MONDE} ; {AFRIQUE} ; {EUROPE} ; {BELGIQUE}},
  booktitle = {},
  journal = {{V}irus {E}volution},
  volume = {11},
  numero = {1},
  pages = {veaf017 [14 ]},
  year = {2025},
  DOI = {10.1093/ve/veaf017},
  URL = {https://www.documentation.ird.fr/hor/fdi:010095321},
}