@article{fdi:010095219,
  title = {{C}ompetition and coevolution drive the evolution and the diversification of {CRISPR} immunity},
  author = {{G}uillemet, {M}. and {C}habas, {H}. and {N}icot, {A}. and {G}atchich, {F}. and {O}rtega {A}bboud, {E}nrique and {B}uus, {C}. and {H}indhede, {L}. and {R}ousseau, {G}.{M}. and {B}ataillon, {T}. and {M}oineau, {S}. and {G}andon, {S}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he diversity of resistance challenges the ability of pathogens to spread and to exploit host populations. {Y}et, how this host diversity evolves over time remains unclear because it depends on the interplay between intraspecific competition among host genotypes and coevolution with pathogens.


{H}ere we study experimentally the effect of coevolving phage populations on the diversification of bacterial {CRISPR} immunity across space and time. {W}e demonstrate that the negative-frequency-dependent selection generated by coevolution is a powerful force that maintains host resistance diversity and selects for new resistance mutations in the host. {W}e also find that host evolution is driven by asymmetries in competitive abilities among different host genotypes. {E}ven if the fittest host genotypes are targeted preferentially by the evolving phages, they often escape extinctions through the acquisition of new {CRISPR} immunity. {T}ogether, these fluctuating selective pressures maintain diversity, but not by preserving the pre-existing host composition. {I}nstead, we repeatedly observe the introduction of new resistance genotypes stemming from the fittest hosts in each population. {T}hese results highlight the importance of competition on the transient dynamics of host-pathogen coevolution.},
  keywords = {},
  booktitle = {},
  journal = {{N}ature {E}cology and {E}volution},
  volume = {6},
  numero = {10},
  pages = {1480--1488},
  ISSN = {2397-334{X}},
  year = {2022},
  DOI = {10.1038/s41559-022-01841-9},
  URL = {https://www.documentation.ird.fr/hor/fdi:010095219},
}