@article{fdi:010095026,
  title = {{D}etection of potential transmission foci of lymphatic filariasis using molecular xenomonitoring in {H}uahine, {F}rench {P}olynesia},
  author = {{L}annuzel, {R}. and {L}ambert, {T}anagra and {D}een, {F}. and {T}ourancheau, {H}. and {M}arie, {J}. and {S}ang, {M}. {A}. {C}. and {M}ervin, {M}. and {S}toll, {B}. and {B}ossin, {H}. {C}. and {M}athieu-{D}aud{\'e}, {F}ran{\c{c}}oise},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {I}n {F}rench {P}olynesia, substantial progress has been achieved in eliminating lymphatic filariasis ({LF}) caused by {W}uchereria bancrofti var. pacifica, a parasite transmitted by the mosquito vector {A}edes polynesiensis. {H}owever, despite multiple rounds of {M}ass {D}rug {A}dministration ({MDA}), {LF} transmission persists on some islands, underscoring the need for robust surveillance to evaluate transmission risks and identify potential transmission foci.{M}ethodology/principal findings {A}n extensive entomological survey combined with a {M}olecular {X}enomonitoring ({MX}) study was conducted on {H}uahine {I}sland in the {L}eeward {I}slands ({S}ociety {I}slands), where new {LF} cases continue to be reported. {A}dult mosquitoes were collected from 420 sampling points across 28 {P}rimary {S}ampling {U}nits ({PSU}s) to map mosquito species distribution and estimate infection prevalence in mosquitoes. {A}mong the 5508 female mosquitoes collected, {A}e. polynesiensis was the predominant species (74%), widely distributed across the island and particularly abundant in some {PSU}s. {O}ther species included {A}edes aegypti (20%) and {C}ulex quinquefasciatus (4%). {M}osquito pools from species of the genera {A}edes and {C}ulex were tested for the presence of {W}. bancrofti using real-time {PCR}. {P}ositive pools were detected in 13 {PSU}s, involving both vector and non-vector {A}edes species, {A}e. polynesiensis (63.6%) and {A}e. aegypti (36.4%). {E}stimated infection prevalence in mosquitoes was higher in {A}e. aegypti (1.1%) than in {A}e. polynesiensis (0.53%), likely reflecting the differences in species abundance and host preferences. {S}everal potential transmission foci were identified, primarily concentrated in the northern part of the island.{C}onclusions/significance {O}ur study demonstrates the effectiveness of {MX} using female {A}edes mosquitoes in identifying potential transmission foci and detecting the presence of {LF} cases in the vicinity on the island of {H}uahine. {T}his approach constitutes a valuable tool for post-{MDA} surveillance in {P}acific {I}slands, where {A}edes mosquitoes are key vectors for {W}. bancrofti, and will effectively inform the targeted implementation of control interventions, including innovative vector control strategies.},
  keywords = {{POLYNESIE} {FRANCAISE}},
  booktitle = {},
  journal = {{PL}o{S} {N}eglected {T}ropical {D}iseases},
  volume = {19},
  numero = {9},
  pages = {e0013492 [17 p.]},
  ISSN = {1935-2735},
  year = {2025},
  DOI = {10.1371/journal.pntd.0013492},
  URL = {https://www.documentation.ird.fr/hor/fdi:010095026},
}