@article{fdi:010094978,
  title = {{C}adinapyridine sesquiterpene alkaloids from {A}rtemisia annua and in vitro cytotoxicity and antiplasmodial activities},
  author = {{F}abre, {N}. and {V}itrai, {A}drien and {B}ourgeade-{D}elmas, {S}andra and {S}affon-{M}erceron, {N}. and {A}moussa, {A}. {M}. {O}. and {L}agnika, {L}. and {A}ubouy, {A}gn{\`e}s and {J}ullian, {V}al{\'e}rie},
  editor = {},
  language = {{ENG}},
  abstract = {{A}rtemisia annua {L}. ({A}. annua) is a medicinal herb that has been used for the last two millennia to treat various diseases. {I}n {A}frican countries, teas prepared from cultivated {A}. annua have been used to treat malaria for the past three decades. {I}n another work, our team investigated the antiplasmodial efficacy of these traditional preparations using a {L}iquid-{C}hromatography-{M}ass {S}pectrometry metabolomic approach on various teas prepared from different batches of {A}. annua collected in {B}enin and in {F}rance and highlighted an original nitrogenous compound. {T}he present work aimed to isolate and characterize its structure. {T}herefore we describe the fractionation of an alkaloid extract from a {B}eninese sample of the plant's aerial parts led to the isolation of two previously undescribed alkaloids, annuanine {A} (1) and annuanine {B} (2) along with the known fabianine (3), all possessing a very unusual skeleton. {T}heir structures were determined through {NMR} and {MS} data analyses. {T}he structure of 1 was further confirmed by single-crystal {X}-ray structural analysis. {C}ompounds 1 and 2 were evaluated for cell-growth inhibition on {C}aco-2, {VERO}, and {T}hp1 cells, as well as on the {P}lasmodium falciparum {F}c{B}1 strain. {U}nfortunately, the two compounds 1 and 2 were inactive in these in vitro models. {C}omparison of {LC}-{HRMS} data between annuanine {B} and {A}. annua tea allowed us to identify it as the nitrogenous compound highlighted by our previous study. {T}hese results enhance the chemical knowledge of this well-known ethnopharmacological herb and highlight a very rare alkaloid skeleton that may have formed from the degradation of artemisinin during plant storage.},
  keywords = {{BENIN} ; {FRANCE}},
  booktitle = {},
  journal = {{PL}o{S} {O}ne},
  volume = {20},
  numero = {9},
  pages = {e0331186 [14 ]},
  year = {2025},
  DOI = {10.1371/journal.pone.0331186},
  URL = {https://www.documentation.ird.fr/hor/fdi:010094978},
}