@article{fdi:010094958,
  title = {{D}ermal trypanosomes in seropositive suspects of gambiense human {A}frican trypanosomiasis in {C}{\^o}te d'{I}voire},
  author = {{N}'{D}jetchi, {M}. {K}. and {T}raor{\'e}, {M}. {B}. and {A}b{\'e}, {I}. and {C}oulibaly, {B}. and {N}anan, {V}. and {K}onan, {T}. and {N}'{D}ri, {L}. and {S}adissou, {I}. and {B}art, {J}ean-{M}athieu and {B}ucheton, {B}runo and {T}ichit, {M}. and {H}ardy, {D}. and {B}oiro, {S}. and {C}amara, {A}. and {T}ravaill{\'e}, {C}. and {C}rouzols, {A}. and {P}etiot, {N}. and {S}egard, {A}deline and {K}ouakou, {L}. and {C}amara, {M}. and {C}amara, {M}. and {K}aba, {D}. and {K}offi, {M}. and {J}amonneau, {V}incent and {R}otureau, {B}.},
  editor = {},
  language = {{ENG}},
  abstract = {{I}n the population at risk of gambiense human {A}frican trypanosomiasis (g{HAT}), the prevalence of extravascular parasite carriage remains unclear. {H}ere, we conducted an observational clinical study in the hypo-endemic g{HAT} foci of {S}infra and {B}onon in {C}{\^o}te d'{I}voire from 2019 to 2022. {A} total of 74 individuals were enrolled, including 45 suspects previously found positive at least once in a serological test for g{HAT} and followed by the national elimination programme of {C}{\^o}te d'{I}voire, as well as 29 seronegative controls. {N}o significant differences between groups were observed for any epidemiological parameters and any clinical parameters at enrolment. {W}hereas trypanosome {DNA} was detected in the blood of 0/29 controls and 2/45 suspects, the presence of extravascular dermal trypanosomes was confirmed by immuno-histochemistry (fixed trypanosome cells) and/or {PCR} (trypanosome {DNA}) in about 1/3 of the suspects (14/45, 31%). {H}owever, no gambiense-specific test was found positive in the present study. {H}ence, the skin could represent an anatomical reservoir for {A}frican trypanosomes sustaining a low level of transmission in hypo-endemic foci.},
  keywords = {{COTE} {D}'{IVOIRE}},
  booktitle = {},
  journal = {{PL}o{S} {N}eglected {T}ropical {D}iseases},
  volume = {19},
  numero = {8},
  pages = {e0013027 [12 p.]},
  ISSN = {1935-2735},
  year = {2025},
  DOI = {10.1371/journal.pntd.0013027},
  URL = {https://www.documentation.ird.fr/hor/fdi:010094958},
}