@article{fdi:010094797,
  title = {{E}pidemiologic, clinical, and therapeutic aspects of formally identified {E}chis romani bites in northern {C}ameroon},
  author = {{C}hippaux, {J}ean-{P}hilippe and {A}mta, {P}. and {M}adec, {Y}. and {N}tone, {R}. and {N}o{\¨e}l, {G}. and {C}lauteaux, {P}. and {B}oum, {Y}., {II} and {N}kwescheu, {A}. {S}. and {T}aieb, {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {S}pecies of the genus {E}chis, particularly those of the 'ocellatus' group, are responsible for the majority of snakebite envenomations and deaths in the savannas of sub-{S}aharan {A}frica. {I}n a clinical study conducted in {C}ameroon, we treated a series of patients bitten by formally identified {E}. romani. {T}he clinical outcomes are described and discussed.{M}ethodology/{P}rincipal findings {S}pecimens brought in by the victim were identified by a herpetologist. {C}linical description and therapeutic management followed a standardized protocol applied by trained physicians. {W}e included 92 patients, 95% of whom (n = 87) were envenomated. {M}ore than one third of the bites occurred during agricultural work, and one quarter in the victim's home. {T}he bite site was the foot in 48 victims (52%) and the hand in 40 others (43%), mostly children and teenagers. {C}ytotoxic syndrome was observed in 84 of the 87 envenomated patients (97%). {H}emostasis disorders were observed in 78 patients (90%), 38 of whom (44%) experienced bleeding during hospitalization. {I}n 5 of the latter (13%), the bleeding recurred, whereas it had stopped after antivenom administration. {A} further 7 patients, who were not bleeding on arrival, experienced late bleeding despite antivenom administration. {F}our patients (4.3%), including one pregnant woman, died. {A}ll were bleeding on arrival. {F}inally, 2 patients (2.2%) had permanent sequelae of moderate severity.{M}ethodology/{P}rincipal findings {S}pecimens brought in by the victim were identified by a herpetologist. {C}linical description and therapeutic management followed a standardized protocol applied by trained physicians. {W}e included 92 patients, 95% of whom (n = 87) were envenomated. {M}ore than one third of the bites occurred during agricultural work, and one quarter in the victim's home. {T}he bite site was the foot in 48 victims (52%) and the hand in 40 others (43%), mostly children and teenagers. {C}ytotoxic syndrome was observed in 84 of the 87 envenomated patients (97%). {H}emostasis disorders were observed in 78 patients (90%), 38 of whom (44%) experienced bleeding during hospitalization. {I}n 5 of the latter (13%), the bleeding recurred, whereas it had stopped after antivenom administration. {A} further 7 patients, who were not bleeding on arrival, experienced late bleeding despite antivenom administration. {F}our patients (4.3%), including one pregnant woman, died. {A}ll were bleeding on arrival. {F}inally, 2 patients (2.2%) had permanent sequelae of moderate severity.{C}onclusion/{S}ignificance {T}his study confirms the frequency and severity of hemorrhagic complications in {E}. romani envenomation. {L}ethality remains high despite antivenom treatment. {C}ytotoxic syndromes, present in 95% of victims, rarely progress to extensive necrosis.},
  keywords = {{CAMEROUN} ; {AFRIQUE} {SUBSAHARIENNE}},
  booktitle = {},
  journal = {{PL}o{S} {N}eglected {T}ropical {D}iseases},
  volume = {19},
  numero = {7},
  pages = {e0013195 [18 p.]},
  ISSN = {1935-2735},
  year = {2025},
  DOI = {10.1371/journal.pntd.0013195},
  URL = {https://www.documentation.ird.fr/hor/fdi:010094797},
}