@article{fdi:010094371,
  title = {{I}nterplay between large low-recombining regions and pseudo-overdominance in a plant genome},
  author = {{S}alson, {M}. and {D}uranton, {M}aud and {H}uynh, {S}tella and {M}ariac, {C}{\'e}dric and {D}ubreuil {T}ranchant, {C}hristine and {O}rjuela, {J}. and {C}ubry, {P}hilippe and {T}huillet, {A}nne-{C}{\'e}line and {B}urgarella, {C}. and de {N}avascues, {M}. and {Z}ekraoui, {L}eila and {C}ouderc, {M}arie and {A}rribat, {S}. and {R}odde, {N}. and {B}arnaud, {A}deline and {F}aye, {A}. and {K}ane, {N}. and {V}igouroux, {Y}ves and {B}erthouly, {C}{\'e}cile},
  editor = {},
  language = {{ENG}},
  abstract = {{T}o what extent overdominance might contribute to the maintenance of genetic diversity within genomes is still an ongoing research question. {P}seudo-overdominance created by the complementation of deleterious alleles in heterozygotes has recently become a subject of particular interest. {S}imulations and theory suggest that pseudo-overdominance may occur in low recombining regions. {H}ere, we conduct a comprehensive investigation of large low-recombining ({LLR}) regions in cultivated populations of pearl millet, an outcrossing diploid {A}frican cereal. {W}e examine seven large regions ranging from 5 to 88 {M}b and six of them are pericentromeric. {T}hese {LLR} regions exhibit an excess of heterozygotes, a distinctive hallmark of overdominance. {T}hey display a tendency toward a higher diversity and a larger ratio of non-synonymous and deleterious variants. {W}e conduct a more in-depth study of the largest 88 {M}b region, identified on chromosome 3. {I}nterestingly, haplotypes of this region have been introgressed from wild relatives. {U}sing long read sequencing, we confirm their strong divergence and the presence of inversions across one of them. {O}ne of the haplotypes seems to be highly deleterious in the homozygous state. {A} total of 17% of the cultivated pearl millet genome exhibit a local population structure suggestive of overdominance or possibly pseudo-overdominance. {O}ur empirical results contribute to the accumulation of knowledge, which will enhance our understanding of the potential role of overdominance or pseudo-overdominance in maintaining genetic diversity, particularly in low recombining regions.},
  keywords = {{SENEGAL}},
  booktitle = {},
  journal = {{N}ature {C}ommunications},
  volume = {16},
  numero = {1},
  pages = {6458 [14 p.]},
  year = {2025},
  DOI = {10.1038/s41467-025-61529-z},
  URL = {https://www.documentation.ird.fr/hor/fdi:010094371},
}