@article{fdi:010094240,
  title = {{I}s malathion oncogenic for mosquitoes ? {A} transcriptomic and histological study of adults derived from malathion exposed larvae},
  author = {{A}rnal, {A}udrey and {B}urioli, {E}. and {J}acquin, {L}. and {L}abrut, {S}. and {D}uchon, {S}t{\'e}phane and {R}ossignol, {M}arie and {N}icolas, {D}. and {U}jvari, {B}. and {D}ujon, {A}. and {M}eliani, {J}. and {A}badie, {J}. and {T}homas, {F}. and {C}orbel, {V}incent},
  editor = {},
  language = {{ENG}},
  abstract = {{M}alathion is a widely used pesticide with potentially oncogenic properties and may have deleterious effects on organism health and fitness. {A}lthough malathion use is now restricted in the {E}uropean {U}nion, it remains widely used for public health campaigns in other parts of the world, particularly for mosquito control. {U}nderstanding its sublethal and long-term effects is thus essential, both for evaluating its ecotoxicological impacts and for anticipating resistance mechanisms. {H}owever, empiric data on its effects in wild organisms - especially in invertebrates - remain limited. {H}ere, we quantitatively investigated whether larval exposure to environmentally realistic concentrations of malathion could affect mosquito tissue structure and gene expression profiles of adult {A}edes aegypti (yellow fever mosquitoes), using both {RNA}-seq and histological approaches. {R}esults show no neoplastic or pre-neoplastic lesions in adults exposed to malathion during larval development, contrary to previous studies in other organisms showing carcinogenic effects of malathion. {H}owever, our differential gene expression analyses revealed significant changes in genes related to mitochondrial function, energy metabolism, and detoxification pathways, suggesting significant physiological impacts of malathion in adults after early-life pesticide exposure. {N}otably, females exhibited stronger transcriptomic responses than males, including the upregulation of genes involved in detoxification (e.g., {P}450 cytochromes), olfactory perception, and stress response, with potential consequences for resistance mechanisms. {O}ur findings underscore the ability of mosquitoes to mount transient molecular responses to environmental pollutants, potentially contributing to the long-term selection of metabolic resistance traits - an outcome with important implications for vector control strategies.},
  keywords = {{M}osquitoes ; {T}ranscriptomics ; {H}istology ; {M}osquito histopathology ; {O}ncogenesis ; {P}ollution ; {P}esticide resistance ; {M}alathion toxicity},
  booktitle = {},
  journal = {{E}cotoxicology and {E}nvironmental {S}afety},
  volume = {301},
  numero = {},
  pages = {118449 [11 p.]},
  ISSN = {0147-6513},
  year = {2025},
  DOI = {10.1016/j.ecoenv.2025.118449},
  URL = {https://www.documentation.ird.fr/hor/fdi:010094240},
}