@article{fdi:010094224,
  title = {{U}nveiling the link between phytoplankton molecular physiology and biogeochemical cycling via genome-scale modeling},
  author = {{R}{\'e}gimbeau, {A}. and {A}umont, {O}livier and {B}owler, {C}. and {G}uidi, {L}. and {J}ackson, {G}. {A}. and {K}arsenti, {E}. and {M}emery, {L}. and {T}agliabue, {A}. and {E}veillard, {D}.},
  editor = {},
  language = {{ENG}},
  abstract = {{E}arth system models ({ESM}s) highly simplify their representation of biological processes, leading to major uncertainty in the impacts of climate change. {D}espite a growing understanding of molecular networks from genomic data, describing how changing phytoplankton physiology affects biogeochemical processes remains elusive. {H}ere, we embed genome-scale models within a state-of-the-art {ESM} to deliver an integrated understanding of how gradients of nutrients modulate the molecular physiology of various plankton. {I}n particular, when applied to {P}rochlorococcus, we find that glycogen and lipid management can be interpreted in terms of acclimation to different environments. {G}eneralized to other phytoplankton such as the diatom {T}halassiosira, we estimate the production of 39 metabolites that constitute hot spots of dissolved organic carbon described by their amount of carbon produced and their diversity of associated metabolites in {ESM}s. {T}his modeling approach shows how genome scale-enabled {ESM}s have the potential to advance our understanding of microbial ecosystem functioning in ocean biogeochemical processes.},
  keywords = {},
  booktitle = {},
  journal = {{S}cience {A}dvances},
  volume = {11},
  numero = {23},
  pages = {eadq3593 [11 p.]},
  year = {2025},
  DOI = {10.1126/sciadv.adq3593},
  URL = {https://www.documentation.ird.fr/hor/fdi:010094224},
}