@article{fdi:010093596,
  title = {{P}ersonal exposure to air pollutants and immune system biomarkers in pregnant women},
  author = {{M}arsal, {A}nouk and {F}rau, {L}. and {C}haperot, {L}. and {A}mine, {I}. and {L}yon-{C}aen, {S}. and {B}oudier, {A}. and {J}affrezo, {J}. {L}. and {E}lazzouzi, {R}. and {P}hilippat, {C}. and {S}upernant, {K}. and {L}epeule, {J}. and {Q}uentin, {J}. and {C}hartier, {R}. and {B}ayat, {S}. and {S}lama, {R}. and {U}zu, {G}a{\¨e}lle and {S}iroux, {V}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he immune function is suspected to play an important role in the health effects of air pollution but it remains poorly investigated in pregnant women. {O}ne-week personal measurements of exposure to nitrogen dioxide ({NO}2), particulate matter with an aerodynamic diameter of <= 2.5 mu m mass concentration ({PM}2.5) and {PM}2.5 oxidative potential ({OP}) were assessed in 270 pregnant women from the {F}rench cohort {SEPAGES}. {PM} filters were analyzed for {PM}2.5 {OP} using the dithiothreitol ({DTT}) and the ascorbic acid ({AA}) assays. {F}rom a blood sample withdrawn at the end of the exposure measurement week, levels of 29 cytokines and chemokines were measured at baseline and after {T} cell and dendritic cell activation with phytohemagglutinin ({PHA}) and resiquimod ({R}848), respectively. {A}ssociations between each air pollutant and each cytokine were assessed using adjusted linear regression models. {A}n increase in {NO}2 exposure was associated with higher interleukin 10 ({IL}-10) and lower {PHA}-activated tumor necrosis factor ({TNF}). {N}o association with {PM}2.5 concentration was observed, but increased exposure to {PM} {OPAA} was associated with lower baseline and {R}848-activated {IL}-8 and increased exposure to {PM} {OPDTT} was associated with higher {PHA}-activated {IL}-17{A}. {O}ur study provides insights into the relationships between air pollution exposure and immune function among pregnant women.},
  keywords = {{I}mmune system ; {C}ytokines ; {P}articulate matter ; {O}xidative potential ; {N}itrogen dioxide ; {P}regnancy ; {FRANCE}},
  booktitle = {},
  journal = {{S}cientific {R}eports - {N}ature},
  volume = {15},
  numero = {1},
  pages = {17672 [12 p.]},
  ISSN = {2045-2322},
  year = {2025},
  DOI = {10.1038/s41598-025-98712-7},
  URL = {https://www.documentation.ird.fr/hor/fdi:010093596},
}