@article{fdi:010093506,
  title = {{U}nveiling the hemolymphatic mi{RN}ome composition of the schistosomiasis vector snail {B}iomphalaria glabrata},
  author = {{D}ametto, {S}. and {G}ourbal, {B}. and {C}haparro, {C}. and {P}inaud, {S}ilvain and {D}uval, {D}.},
  editor = {},
  language = {{ENG}},
  abstract = {{M}i{RNA}s are single-stranded short noncoding sequences which display crucial roles on gene transcription regulation in many biological processes especially such as embryonic development, cell proliferation or apoptosis. {A}lso, they are recognized for triggering the host's internal defence mechanisms and immune cell responses thereby playing crucial role in host-parasite interactions. {I}n the present study, a snap-shot of mi{RNA}s, referred to as the mi{RN}ome, is described from the hemolymph, the main immune-related compartment of {B}iomphalaria glabrata snails, one of the intermediate hosts of the trematode parasite {S}chistosoma mansoni, the causative agent of schistosomiasis. {A} high throughput sequencing approach of small {RNA}s has revealed the presence of 63 mi{RNA}s in the hemolymphatic compartment. {M}ollusc-specific mi{RNA}s including bgl-mi{R}-1985-5p and bgl-mi{R}1984-5p were identified, along with 25 novel mi{RNA}s. {B}ioinformatic predictions, thanks to multiple software tools, helped us to identify more than 6000 potential mi{RNA} target gene candidates. {A}mong them is {B}g{TEP}1, a complement-like factor involved in parasite clearance. {I}nterestingly, this factor appeared to be targeted by a newly identified mi{RNA}, named bgl-mi{R}-22707-5p. {O}ur study underscores the inherent diversity of mi{RNA}s in the hemolymph of {B}. glabrata and discusses their potential role in the regulation of the snail's innate immune response.},
  keywords = {{B}iomphalaria glabrata ; {H}emocytes ; mi{RNA} ; {S}mall {RNA}s ; {H}ost-parasite ; interaction ; {BRESIL}},
  booktitle = {},
  journal = {{C}urrent {R}esearch in {P}arasitology and {V}ector-{B}orne {D}iseases},
  volume = {7},
  numero = {},
  pages = {100262 [14 ]},
  ISSN = {2667-114{X}},
  year = {2025},
  DOI = {10.1016/j.crpvbd.2025.100262},
  URL = {https://www.documentation.ird.fr/hor/fdi:010093506},
}