@article{fdi:010093485,
  title = {{S}erological response to mpox and direct virus detection in asymptomatic patient prior to the first diagnosed case : a retrospective study of the 2022 {M}ontpellier epidemic},
  author = {{H}enry, {S}. and {C}hampagne, {M}aeliss and {A}youba, {A}hidjo and {P}eeters, {M}artine and {R}io, {L}. {P}. and {B}istoquet, {M}. and {C}ordellat, {C}. {A}. and {G}odreuil, {S}. and {T}uaillon, {E}. and {F}oulongne, {V}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he {M}pox (formerly monkeypox) outbreak in 2022 presented unprecedented challenges, including widespread transmission in non-endemic regions, particularly among men who have sex with men. {T}his study examines {M}pox infections in {M}ontpellier, {F}rance, focusing on diagnostic testing, serological profiles, and potential asymptomatic cases, based on data from {M}ontpellier {U}niversity {H}ospital. {W}e retrospectively analyzed results from 91 patients tested positive for {M}pox {DNA}. {A}ntibody responses were monitored using novel {M}pox virus peptide-based serological assays. {O}ur findings highlight that {MPXV} antibodies can develop early in infection, peaking within 2 weeks to 3 months, though responses varied by antigen type. {A}dditionally, asymptomatic {M}pox infections were suggested, with virus detected in blood, urine, anal, oral and genital swabs screened {S}exual {T}ransmitted {I}nfection samples. {N}otably, viral presence was confirmed in {M}ontpellier samples as early as mid-{M}ay 2022, before the first known symptomatic case in {H}ospital, in the same period as the first official case in {F}rance. {T}his study underscores the need for expanded screening in high-risk clinics to control {M}pox spread and supports the potential utility of serological assays for broad immune profiling. {E}nhanced diagnostic tools and proactive surveillance in sexual health settings are recommended to improve outbreak response and prevent further transmission.},
  keywords = {asymptomatic screening ; genital swab ; {H}3{L} serology ; {M}pox outbreak ; {M}pox viremia ; pre-epidemic case ; {FRANCE} ; {MONTPELLIER}},
  booktitle = {},
  journal = {{J}ournal of {M}edical {V}irology},
  volume = {97},
  numero = {5},
  pages = {e70365 [10 p.]},
  ISSN = {0146-6615},
  year = {2025},
  DOI = {10.1002/jmv.70365},
  URL = {https://www.documentation.ird.fr/hor/fdi:010093485},
}