@article{fdi:010093468,
  title = {{P}renatal hemoglobin concentration and long-term child neurocognitive development},
  author = {{M}ireku, {M}. {O}. and {B}oivin, {M}. {J}. and {Z}oumenou, {R}. and {G}arrison, {A}. and {C}ot, {M}ichel and {A}lao, {J}. and {F}ievet, {N}adine and {M}assougbodji, {A}. and {B}odeau-{L}ivinec, {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A}nemia in pregnancy, defined by a hemoglobin level ({H}b) of less than 110 g/{L}, contributes to infant mortality and morbidity in sub-{S}aharan {A}frica. {M}aternal {H}b changes physiologically and pathologically during pregnancy. {H}owever, the impact of these changes on long-term child neurocognitive function is unknown. {T}his study therefore investigates the association between {H}b at specific antenatal care visits and prenatal {H}b trajectories during pregnancy and long-term child neurocognitive function. {W}e analyzed data from a prospective cohort study that included 6-year-old singleton children born to women enrolled before 29 weeks of gestation into an antimalarial drug clinical trial. {H}emoglobin level was analyzed from venous blood collected at least twice during pregnancy and at delivery. {W}e used group-based trajectory modeling to identify distinct prenatal {H}b trajectories. {I}n total, 478 children (75.1% of eligible children) had assessment of cognitive and motor functions at 6 years of age. {T}hree distinct {H}b trajectories were identified: persistently anemic ({H}b <110 g/{L} throughout the second and third trimesters), anemic to nonanemic ({H}b <110 g/{L} at second trimester with increasing {H}b toward the third trimester to {H}b >= 110 g/{L}), and persistently nonanemic ({H}b >= 110 g/{L} throughout the second and third trimesters). {C}hildren of women in the persistently anemic and anemic-to-nonanemic groups had significantly lower neurocognitive scores than children of women in the persistently nonanemic group (beta =-6.8, 95% {CI}:-11.7 to-1.8; and beta =-6.3, 95% {CI}:-10.4 to-2.2, respectively). {T}he study shows that maintaining an elevation of {H}b at or above 110 g/{L} from the second to third trimester of pregnancy may be associated with optimal long-term child neurocognitive function.},
  keywords = {{BENIN} ; {AFRIQUE} {SUBSAHARIENNE}},
  booktitle = {},
  journal = {{A}merican {J}ournal of {T}ropical {M}edicine and {H}ygiene},
  volume = {112},
  numero = {3},
  pages = {692--698},
  ISSN = {0002-9637},
  year = {2025},
  DOI = {10.4269/ajtmh.24-0643},
  URL = {https://www.documentation.ird.fr/hor/fdi:010093468},
}