@article{fdi:010093440,
  title = {{M}ultigenerational ecotoxicity of tris(2-butoxyethyl) phosphate to the tropical water flea {C}eriodaphnia cornuta and probabilistic ecological risk assessment in freshwater environments},
  author = {{N}guyen, {T}. {D}. and {N}guyen, {V}. and {D}inh, {K}. and {W}iegand, {C}. and {W}ang, {Z}. and {B}aduel, {C}hristine and {P}ham, {T}. {L}. and {D}uong, {T}. {T}. and {N}guyen, {Q}. {H}. and {D}o, {V}. and {L}e, {T}. {P}. {Q}. and {H}uang, {Y}. {C}. and {D}ao, {T}. {S}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he widespread use of the organophosphorus flame retardant tris(2-butoxyethyl) phosphate ({TBOEP}) and its presence in aquatic environments pose a hazard to wildlife. {T}his study investigates the chronic ecotoxicity of {TBOEP} at environmentally relevant concentrations (6 +/- 0.7 mu g {L}-1) in the tropical water flea {C}eriodaphnia cornuta over seven generations. {D}elayed toxicity emerged from the second generation ({F}1) to the fourth generation ({F}3), affecting survival, body length, and fertility. {R}ecovery occurred in {F}4, followed by complete inhibition in {F}5 and {F}6, where no organisms survived beyond day 10. {P}opulation dynamics revealed minimal growth in {F}5, leading to extinction by {F}6. {T}his is the first study to demonstrate the multigenerational lethal effects of {TBOEP} at environmentally relevant concentrations, highlighting ecological threats to {C}. cornuta and other sensitive species. {T}he mechanisms underlying these effects remain unclear and require sub-organismal investigation. {T}he chronic predicted no-effect concentration, estimated at 8.64 mu g {L}-1, exceeds the tested concentration and therefore may not adequately protect vulnerable species. {E}cological risk assessments based on {TBOEP} concentrations detected in surface waters since 2014 suggest potential risks at elevated levels in specific locations across multiple countries. {A}dditional research is essential to validate {TBOEP}'s toxicity across species under chronic and multigenerational exposure. {C}urrent ecological risk assessments likely underestimate {TBOEP}'s threat to aquatic ecosystems, emphasizing the need for reassessment to better safeguard biodiversity.},
  keywords = {{W}ater quality criteria ; {P}redicted no-effect concentration ; {S}pecies sensitivity distribution ; {T}ropical daphnid ; {F}lame retardants ; {M}ultigenerational toxicity testing ; {D}elayed toxicity},
  booktitle = {},
  journal = {{A}quatic {T}oxicology},
  volume = {283},
  numero = {},
  pages = {107363 [13 ]},
  ISSN = {0166-445{X}},
  year = {2025},
  DOI = {10.1016/j.aquatox.2025.107363},
  URL = {https://www.documentation.ird.fr/hor/fdi:010093440},
}