@article{fdi:010093401,
  title = {{W}hole genome sequencing and genetic diversity of respiratory viruses detected in children with acute respiratory infections : a one-year cross-sectional study in {S}enegal},
  author = {{N}diaye, {A}. {J}. {S}. and {C}ortaderona, {S}. and {D}elorme, {L}. and {B}eye, {M}. and {K}acel, {I}. and {B}ossi, {V}. and {L}o, {G}. and {L}eye, {N}. and {P}adane, {A}. and {D}iop-{N}diaye, {H}. and {K}ane, {C}. {T}. and {D}iagne, {N}. {R}. and {S}okhna, {C}heikh and {M}boup, {S}. and {F}ournier, {P}. {E}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A}cute respiratory infections ({ARI}) are a health priority, especially in countries with limited resources. {T}hey are a major cause of morbidity and mortality, especially among children and the elderly. {I}n {S}enegal, the endemic circulation of respiratory viruses other than influenza has been demonstrated. {H}owever, there is a paucity of data exploring the genetic diversity of these viruses based on whole-genome sequencing. {I}n this study, we present data on the genetic diversity of respiratory viruses in children under 15 years old in {S}enegal, including an overview of the different pathogens detected. {B}etween {N}ovember 2022 and {N}ovember 2023, we collected nasopharyngeal swabs from children seen in curative consultations for symptoms of acute respiratory infections. {O}f the 156 children included, 73.7% tested positive for at least one pathogen. {T}he most frequently detected virus was rhinovirus (50.0%), followed by influenza {B} (41.6%) and human parainfluenza virus type 3 (7.6%). {C}ombinations of rhinovirus/influenza {B}, human parainfluenza virus type 2/human parainfluenza virus type 4, and rhinovirus/influenza {B}/adenovirus were the most frequently identified. {A} statistically significant association was detected between some of the viruses detected. {A} high genetic diversity of respiratory viruses circulating in children was revealed. {T}he strains were phylogenetically close to various strains circulating worldwide, suggesting a global circulation of respiratory viruses. {O}ur study provides the first complete genome sequences of human parainfluenza viruses type 2, 3, 4 and human bocavirus from {S}enegal and thus contributes to the enrichment of international databases on sequences from {S}enegal and underlines the importance of sequencing in the dynamics of pathogen circulation.},
  keywords = {acute respiratory infections ; children ; {NGS} ; {S}enegal ; virus ; whole ; genome ; {SENEGAL}},
  booktitle = {},
  journal = {{J}ournal of {M}edical {V}irology},
  volume = {97},
  numero = {4},
  pages = {e70342 [18 p.]},
  ISSN = {0146-6615},
  year = {2025},
  DOI = {10.1002/jmv.70342},
  URL = {https://www.documentation.ird.fr/hor/fdi:010093401},
}