%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Kleynhans, J.
%A Dall'Amico, L.
%A Gauvin, Laëtitia
%A Tizzoni, M.
%A Maloma, L.
%A Walaza, S.
%A Martinson, N.A.
%A von Gottberg, A.
%A Wolter, N.
%A Makhasi, M.
%A Cohen, C.
%A Cattuto, C.
%A Tempia, S.
%T Association of close-range contact patterns with SARS-CoV-2 : a household transmission study
%D 2023
%L fdi:010093231
%G ENG
%J eLife
%@ 2050-084X
%K AFRIQUE DU SUD
%K KLERKSDORP ; SOWETO
%M ISI:001035382500001
%P e84753 [26 ]
%R 10.7554/elife.84753
%U https://www.documentation.ird.fr/hor/fdi:010093231
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2025-04/010093231.pdf
%V 12
%W Horizon (IRD)
%X Background: Households are an important location for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission, especially during periods when travel and work was restricted to essential services. We aimed to assess the association of close-range contact patterns with SARS-CoV-2 transmission. Methods: We deployed proximity sensors for two weeks to measure face-to-face interactions between household members after SARS-CoV-2 was identified in the household, in South Africa, 2020-2021. We calculated the duration, frequency, and average duration of close-range proximity events with SARS-CoV-2 index cases. We assessed the association of contact parameters with SARS-CoV-2 transmission using mixed effects logistic regression accounting for index and household member characteristics. Results: We included 340 individuals (88 SARS-CoV-2 index cases and 252 household members). On multivariable analysis, factors associated with SARS-CoV-2 acquisition were index cases with minimum Ct value <30 (aOR 16.8 95% CI 3.1-93.1) vs >35, and female contacts (aOR 2.5 95% CI 1.3-5.0). No contact parameters were associated with acquisition (aOR 1.0-1.1) for any of the duration, frequency, cumulative time in contact, or average duration parameters. Conclusions: We did not find an association between close-range proximity events and SARS-CoV-2 household transmission. Our findings may be due to study limitations, that droplet-mediated transmission during close-proximity contacts plays a smaller role than airborne transmission of SARS-CoV-2 in the household, or due to high contact rates in households.
%$ 050MEDECI ; 052MALTRA03 ; 106PROSO