Massey A. auteur aut IRD Boennec C. auteur aut IRD Restrepo Ortiz Claudia auteur aut IRD Blanchet C. auteur aut IRD Alizon S. auteur aut IRD Sofonea M.T. auteur aut IRD text journalArticle eng text/pdf reformatted digital access Projects such as the European Covid-19 Forecast Hub publish forecasts on the national level for new deaths, new cases, and hospital admissions, but not direct measurements of hospital strain like critical care bed occupancy at the sub-national level, which is of particular interest to health professionals for planning purposes. We present a sub-national French framework for forecasting hospital strain based on a non-Markovian compartmental model, its associated online visualisation tool and a retrospective evaluation of the real-time forecasts it provided from January to December 2021 by comparing to three baselines derived from standard statistical forecasting methods (a naive model, auto-regression, and an ensemble of exponential smoothing and ARIMA). In terms of median absolute error for forecasting critical care unit occupancy at the two-week horizon, our model only outperformed the naive baseline for 4 out of 14 geographical units and underperformed compared to the ensemble baseline for 5 of them at the 90% confidence level (n = 38). However, for the same level at the 4 week horizon, our model was never statistically outperformed for any unit despite outperforming the baselines 10 times spanning 7 out of 14 geographical units. This implies modest forecasting utility for longer horizons which may justify the application of non-Markovian compartmental models in the context of hospital-strain surveillance for future pandemics. specialized FRANCE 056 050 20 5 e1012124 [22 ] 2024 1553-7358 https://www.documentation.ird.fr/hor/fdi:010093167 10.1371/journal.pcbi.1012124 1553-7358 [F B010093167] https://www.documentation.ird.fr/hor/fdi:010093167 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2025-04/010093167.pdf IRD - Base Horizon / Pleins textes 2025-03-05 2025-11-06 fdi:010093167 fre