%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Roux, H.F.G.
%A Touret, Franck
%A Rathelot, P.
%A Sciò, P.
%A Coluccia, A.
%A Vanelle, P.
%A Roche, M.
%T Non-Polio Enterovirus inhibitors : scaffolds, targets, and potency - what's new ?
%D 2024
%L fdi:010093051
%G ENG
%J ACS Infectious Diseases
%@ 2373-8227
%M ISI:001382233700001
%N 1
%P 21-46
%R 10.1021/acsinfecdis.4c00606
%U https://www.documentation.ird.fr/hor/fdi:010093051
%V 11
%W Horizon (IRD)
%X Enterovirus (EV) is a genus that includes a large diversity of viruses spread around the world. They are the main cause of numerous diseases with seasonal clusters, like hand-foot-mouth disease (HFMD). A vaccine is marketed in China for the prevention of HFMD caused by EV-A71. Despite the need, no antiviral is marketed to date. Therefore, several compounds have been currently evaluated to inhibit non-polio Enterovirus (NPEV), namely direct antiviral agents and host target inhibitor. We propose to make a review of the latest molecules evaluated as NPEV inhibitors and to summarize structure-activity relationships between these inhibitors and their target. We provide access to all recent information on Enterovirus inhibitors, regardless of the species,


to facilitate the design of future broad-spectrum drugs.
%$ 052 ; 050