@article{fdi:010093051, title = {{N}on-{P}olio {E}nterovirus inhibitors : scaffolds, targets, and potency - what's new ?}, author = {{R}oux, {H}.{F}.{G}. and {T}ouret, {F}ranck and {R}athelot, {P}. and {S}ciò, {P}. and {C}oluccia, {A}. and {V}anelle, {P}. and {R}oche, {M}.}, editor = {}, language = {{ENG}}, abstract = {{E}nterovirus ({EV}) is a genus that includes a large diversity of viruses spread around the world. {T}hey are the main cause of numerous diseases with seasonal clusters, like hand-foot-mouth disease ({HFMD}). {A} vaccine is marketed in {C}hina for the prevention of {HFMD} caused by {EV}-{A}71. {D}espite the need, no antiviral is marketed to date. {T}herefore, several compounds have been currently evaluated to inhibit non-polio {E}nterovirus ({NPEV}), namely direct antiviral agents and host target inhibitor. {W}e propose to make a review of the latest molecules evaluated as {NPEV} inhibitors and to summarize structure-activity relationships between these inhibitors and their target. {W}e provide access to all recent information on {E}nterovirus inhibitors, regardless of the species, to facilitate the design of future broad-spectrum drugs.}, keywords = {}, booktitle = {}, journal = {{ACS} {I}nfectious {D}iseases}, volume = {11}, numero = {1}, pages = {21--46}, ISSN = {2373-8227}, year = {2024}, DOI = {10.1021/acsinfecdis.4c00606}, URL = {https://www.documentation.ird.fr/hor/fdi:010093051}, }