@article{fdi:010093046,
  title = {{F}rom the "{O}ne-{M}olecule, {O}ne-{T}arget, {O}ne-{D}isease" concept towards {L}ooking for multi-target therapeutics for treating {N}on-{P}olio {E}nterovirus ({NPEV}) {I}nfections},
  author = {{R}oux, {H}. and {T}ouret, {F}ranck and {R}athelot, {P}. and {V}anelle, {P}. and {R}oche, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{N}on-polio enteroviruses ({NPEV}s), namely coxsackieviruses ({CV}), echoviruses ({E}), enteroviruses ({EV}), and rhinoviruses ({RV}), are responsible for a wide variety of illnesses. {S}ome infections can progress to life-threatening conditions in children or immunocompromised patients. {T}o date, no treatments have been approved. {S}everal molecules have been evaluated through clinical trials without success. {T}o overcome these failures, the multi-target directed ligand ({MTDL}) strategy could be applied to tackle enterovirus infections. {T}his work analyzes registered clinical trials involving antiviral drugs to highlight the best candidates and develops filters to apply to a selection for {MTDL} synthesis. {W}e explicitly stated the methods used to answer the question: which solution can fight {NPEV}s effectively ? {W}e note the originality and relevance of this proposal in relation to the state of the art in the enterovirus-inhibitors field. {S}everal combinations are possible to broaden the antiviral spectrum and potency. {W}e discuss data related to the virus and data related to each {LEAD} compound identified so far. {O}verall, this study proposes a perspective on different strategies to overcome issues identified in clinical trials and evaluate the "{MTDL}" potential to improve the efficacy of drugs, broaden the antiviral targets, possibly reduce the adverse effects, drug design costs and limit the selection of drug-resistant virus variants.},
  keywords = {},
  booktitle = {},
  journal = {{P}harmaceuticals},
  volume = {17},
  numero = {9},
  pages = {1218 [41 ]},
  ISSN = {1424-8247},
  year = {2024},
  DOI = {10.3390/ph17091218},
  URL = {https://www.documentation.ird.fr/hor/fdi:010093046},
}