Nazmul Islam M. auteur aut IRD De Allegri M. auteur aut IRD Bonnet Emmanuel auteur aut IRD Sarker M. auteur aut IRD Goudet J.M. auteur aut IRD Franceschin L. auteur aut IRD Ridde Valéry auteur aut IRD text journalArticle eng text/pdf reformatted digital access Bangladesh completed a primary series of COVID-19 vaccinations for about 86 individuals per 100 population as of 5 July 2023. However, ensuring higher coverage in vulnerable areas is challenging. We report on the COVID-19 vaccine uptake and associated factors among adults in two vulnerable areas in Bangladesh. We conducted a cross-sectional study between August and September 2022 in Duaripara, a slum in northeast Dhaka (in-migration site), and Tala, a disaster-prone sub-district in southwest Satkhira (out-migration site). We surveyed 1,239 adults in Duaripara and 1,263 adults in Tala from 625 and 596 randomly selected households, respectively. We reported coverage and examined associations between the uptake and demographic and socioeconomic characteristics using multilevel mixed-effects generalized linear regression models. We checked for spatial autocorrelation to assess geographical patterns in vaccine distribution. First- and second-dose coverage was about 91% and 80.4% in Duaripara and 96.6% and 92.2% in Tala, respectively. Individuals above 40 were more likely to be vaccinated (IRR: 1.12, p-value = 0.04 for Duaripara, and IRR: 1.14, p-value <0.01 for Tala). Professions requiring more outdoor interactions had a higher likelihood of receiving the vaccine. In Tala, television access (IRR: 2.09, p-value <0.01) and micro-credit membership (IRR: 1.50, p-value = 0.05) were positively associated with receiving a booster dose and negatively associated with smart-phone access (IRR: 0.58, p-value = 0.03). Moreover, temporarily migrated respondents were more likely to be unvaccinated (IRR: 0.87, p-value = 0.04). Income was not associated, indicating equitable distribution. Moreover, no geographical clustering was detected. The credit for high COVID-19 vaccine coverage in Bangladesh can be attributed to the country's longstanding success in implementing immunization programs, which relied on community mobilization and effective health education to generate demand. However, to ensure comprehensive coverage in vulnerable areas, targeted interventions can help increase uptake by addressing specific sociodemographic differences. specialized BANGLADESH 050 056 106 021 5 1 e0004178 [22 ] 2025 2767-3375 https://www.documentation.ird.fr/hor/fdi:010093007 10.1371/journal.pgph.0004178 2767-3375 [F B010093007] https://www.documentation.ird.fr/hor/fdi:010093007 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2025-02/010093007.pdf IRD - Base Horizon / Pleins textes 2025-01-24 2025-11-04 fdi:010093007 fre