%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Gorse, L.
%A Plessis, L.
%A Wearne, S.
%A Paradis, M.
%A Pinilla, M.
%A Chua, R.
%A Lim, S. S.
%A Pelluz, E.
%A Toh, G. A.
%A Mazars, R.
%A Bomfim, C.
%A Hervé, F.
%A Lhaute, K.
%A Réveillon, D.
%A Suire, B.
%A Ravon-Katossky, L.
%A Benoist, T.
%A Fromont, L.
%A Péricat, D.
%A Mertens, K. N.
%A Derrien, A.
%A Terre-Terrillon, A.
%A Chomérat, N.
%A Bilien, G.
%A Séchet, V.
%A Carpentier, L.
%A Fall, M.
%A Sonko, A.
%A Hakim, H.
%A Sadio, N.
%A Bourdeaux, J.
%A Cougoule, C.
%A Henras, A. K.
%A Perez-Oliva, A. B.
%A Brehmer, Patrice
%A Roca, F. J.
%A Zhong, F. L.
%A Common, J.
%A Meunier, E.
%A Hess, P.
%T Portimine A toxin causes skin inflammation through ZAK  A-dependent NLRP1 inflammasome activation
%D 2025
%L fdi:010092782
%G ENG
%J EMBO Molecular Medicine
%@ 1757-4676
%K Skin Pathology ; Environmental Toxins ; Ribotoxic Stress Response ; NLRP1 ; Inflammasome
%M ISI:001420044400001
%P [28 ]
%R 10.1038/s44321-025-00197-4
%U https://www.documentation.ird.fr/hor/fdi:010092782
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2025-04/010092782.pdf
%V [Early access]
%W Horizon (IRD)
%X In 2020-2021, a "mysterious illness" struck Senegalese fishermen, causing severe acute dermatitis in over one thousand individuals following exposure through drift-net fishing activity. Here, by performing deep analysis of the environmental samples we reveal the presence of the marine dinoflagellate Vulcanodinium rugosum and its associated cyclic imine toxins. Specifically, we show that the toxin PortimineA, strongly enriched in environmental samples, impedes ribosome function in human keratinocytes, which subsequently activates the stress kinases ZAK alpha and P38 and promotes the nucleation of the human NLRP1 inflammasome, leading to the release of IL-1 beta/IL-18 pro-inflammatory cytokines and cell death. Furthermore, cell-based models highlight that naturally occurring mutations in the P38-targeted sites of human NLRP1 are unable to respond to PortimineA exposure. Finally, the development and use of human organotypic skins and zebrafish models of PortimineA exposure demonstrate that the ZAK alpha-NLRP1 axis drives skin necrosis and inflammation. Our results exemplify the threats to human health caused by emerging environmental toxins and identify ZAK alpha and NRLP1 as important pharmacological targets to mitigate PortimineA toxicity.
%$ 050 ; 020 ; 034