@article{fdi:010092769,
  title = {{I}mpact of seasonal malaria chemoprevention timing on clinical malaria incidence dynamics in the {K}edougou region, {S}enegal},
  author = {{K}azanga, {B}. and {B}a, {E}. {H}. and {L}egendre, {E}. and {C}issoko, {M}. and {F}leury, {L}aurence and {B}erard, {L}ucas and {D}iop, {A}. and {S}okhna, {C}heikh and {D}anfakha, {F}. and {S}agara, {I}. and {N}diaye, {J}. {L}. and {G}audart, {J}. and {L}andier, {J}ordi},
  editor = {},
  language = {{ENG}},
  abstract = {{S}easonal malaria chemoprevention ({SMC}) with sulfadoxine-pyrimethamine and amodiaquine is recommended by the {W}orld {H}ealth {O}rganization since 2012 for clinical malaria prevention in children in the {S}ahelian region of {A}frica. {I}n {S}enegal, {SMC} implementation began in 2013 and is given to children under 10 years old. {T}his study aimed to describe clinical malaria incidence in the general population during routine {SMC} implementation and to analyse how {SMC} timing impacted clinical malaria dynamics in eligible children. {W}e conducted an ecological study in the {K}edougou region of {S}enegal in 27 villages included in the {B}andafassi {H}ealth and {D}emographic {S}urveillance {S}ystem ({HDSS}). {W}e calculated weekly {P}lasmodium falciparum malaria incidence by age group using malaria case data recorded by community health workers and health-posts, and population denominators obtained from {B}andafassi {H}ealth and {D}emographic {S}urveillance {S}ystem. {W}e used negative binomial generalized additive multilevel models to analyse the incidence of clinical episodes in children under 10 years during the expected {SMC} prophylactic period and at the end of the transmission period. {M}alaria incidence was strongly seasonal with a high transmission period starting in {J}une. {C}hildren under {SMC} presented an overall lower incidence compared to older children and young adults. {A}mong children eligible for {SMC}, the incidence was lowest for approximately 3 weeks after treatment administration and increased subsequently, suggesting a gradual loss of protection. {A}t the end of the high transmission period, a higher malaria incidence was recorded from the 3rd to 6th week after the week of administration of the fourth (final) {SMC} round. {W}hile protecting children under 10 years, {SMC} warrants adjustment to reduce exposure before the next round, to increase protection of 5-9 years, and to cover the high transmission period completely. {T}he addition of a 5th round of {SMC} in 2023 was necessary to cover the end of the transmission season, but individual-level studies are required to ensure that drug efficacy and adequate dosing are maintained.},
  keywords = {{SENEGAL}},
  booktitle = {},
  journal = {{PL}o{S} {G}lobal {P}ublic {H}ealth},
  volume = {5},
  numero = {1},
  pages = {e0003197 [15 p.]},
  year = {2025},
  DOI = {10.1371/journal.pgph.0003197},
  URL = {https://www.documentation.ird.fr/hor/fdi:010092769},
}