@article{fdi:010092706,
  title = {{T}oxoplasma gondii from {G}abonese forest, {C}entral {A}frica : {F}irst report of an {A}frican wild strain},
  author = {{G}alal, {L}. and {F}ritz, {M}. and {B}ecquart, {P}ierre and {P}assebosc-{F}aure, {K}. and {P}lault, {N}. and {B}oundenga, {L}. and {M}ombo, {I}. {M}. and {K}ombila, {L}. {B}. and {M}ebaley, {T}. {N}. and {L}enguiya, {L}. {H}. and {N}goubangoye, {B}. and {N}'{D}ilimabaka, {N}. and {P}rugnolle, {F}. and {F}orestier, {L}. and {G}ebremedhin, {E}. {Z}. and {L}eroy, {E}ric and {M}aganga, {G}. {D}. and {M}ercier, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he protozoan {T}oxoplasma gondii is a ubiquitous and highly prevalent parasite that can theoretically infect all warm-blooded vertebrates. {I}n humans, toxoplasmosis causes infections in both immunodeficient and immunocompetent patients, congenital toxoplasmosis, and ocular lesions. {T}hese manifestations have different degrees of severity. {C}linical severity is determined by multiple factors, including the genotype of the {T}. gondii strain involved in the infection. {T}. gondii exhibits remarkable genetic diversity, which varies according to geography and ecotype (domestic or wild). {P}revious studies have demonstrated that wild strains of {T}. gondii are of particular epidemiological interest, as they have been associated with more severe forms of toxoplasmosis in different regions of the world. {H}owever, no data on wild strains of {T}. gondii are available from {A}frica. {I}n this study, we describe for the first time a wild {T}. gondii strain from {A}frica. {W}ild animals from the forest environment of {G}abon, {C}entral {A}frica, were screened for chronic infection with {T}. gondii using quantitative {PCR}. {T}he infecting {T}. gondii strains were genotyped whenever possible by the analysis of 15 microsatellite markers and by whole-genome sequencing. {A} new {T}. gondii genotype was identified in the {DNA} extract from a heart sample of a duiker ({C}ephalophus sp.) and was found to be highly divergent from previously described {T}. gondii populations worldwide, including those from domestic environments in {G}abon. {T}his discovery suggests the existence of a wild {T}. gondii population in {A}frica. {T}he role of wild {T}. gondii strains in the incidence of severe toxoplasmosis in {A}frica remains unclear and requires further investigation.},
  keywords = {{GABON}},
  booktitle = {},
  journal = {{PL}o{S} {N}eglected {T}ropical {D}iseases},
  volume = {19},
  numero = {1},
  pages = {e0012214 [15 p.]},
  ISSN = {1935-2735},
  year = {2025},
  DOI = {10.1371/journal.pntd.0012214},
  URL = {https://www.documentation.ird.fr/hor/fdi:010092706},
}