@article{fdi:010092702,
  title = {{M}alian field isolates provide insight into {P}lasmodium malariae intra-erythrocytic development and invasion},
  author = {{D}ao, {F}. and {N}iangaly, {A}. and {S}ogore, {F}. and {W}ague, {M}. and {D}abitao, {D}. and {G}oita, {S}. and {H}adara, {A}. {S}. and {D}iakite, {O}. and {M}aiga, {M}. and {M}aiga, {F}. {O}. and {C}azevieille, {C}. and {C}assan, {C}{\'e}cile and {T}alman, {A}rthur and {D}jimde, {A}. {A}. and {M}arin-{M}enendez, {A}. and {D}emb{\'e}l{\'e}, {L}.},
  editor = {},
  language = {{ENG}},
  abstract = {{P}lasmodium malariae is the third most prevalent human malaria parasite species and contributes significantly to morbidity. {N}evertheless, our comprehension of this parasite's biology remains limited, primarily due to its frequent co-infections with other species and the lack of a continuous in vitro culture system. {T}o effectively combat and eliminate this overlooked parasite, it is imperative to acquire a better understanding of this species. {I}n this study, we embarked on an investigation of {P}. malariae, including exploring its clinical disease characteristics, molecular aspects of red blood cell ({RBC}) invasion, and host-cell preferences. {W}e conducted our research using parasites collected from infected individuals in {M}ali. {O}ur findings revealed anaemia in most of {P}. malariae infected participants presented, in both symptomatic and asymptomatic cases. {R}egarding {RBC} invasion, quantified by an adapted flow cytometry based method, our study indicated that none of the seven antibodies tested, against receptors known for their role in {P}. falciparum invasion, had any impact on the ability of {P}. malariae to penetrate the host cells. {H}owever, when {RBC}s were pre-treated with various enzymes (neuraminidase, trypsin, and chymotrypsin), we observed a significant reduction in {P}. malariae invasion, albeit not a complete blockade. {F}urthermore, in a subset of {P}. malariae samples, we observed the parasite's capability to invade reticulocytes. {T}hese results suggest that {P}. malariae employs alternative pathways to enter {RBC}s of different maturities, which may differ from those used by {P}. falciparum.},
  keywords = {{MALI}},
  booktitle = {},
  journal = {{PL}o{S} {N}eglected {T}ropical {D}iseases},
  volume = {19},
  numero = {1},
  pages = {e0012790 [20 p.]},
  ISSN = {1935-2735},
  year = {2025},
  DOI = {10.1371/journal.pntd.0012790},
  URL = {https://www.documentation.ird.fr/hor/fdi:010092702},
}