@article{fdi:010092666,
  title = {{V}iscoelastic study of hemostasis disorders associated with {E}chis ocellatus {E}nvenoming in {N}orth {B}enin {U}sing a quantra analyzer},
  author = {{L}arr{\'e}ch{\'e}, {S}. and {C}hacha, {R}. {B}. and {S}odjinou, {N}. and {O}uorou, {S}. {A}. and {G}anhouingnon, {E}. and {L}ayo, {E}. {A}. and {M}{\'e}garbane, {B}. and {M}assougbodji, {A}. and {C}hippaux, {J}ean-{P}hilippe},
  editor = {},
  language = {{ENG}},
  abstract = {{E}chis ocellatus envenomings are a public health problem in {W}est {A}frica, leading to bleeding and hypocoagulability. {T}he aim of this study was to assess the hemostasis disorders associated with {E}. ocellatus envenoming. {E}nvenomed patients with an abnormal whole blood clotting test ({WBCT}) were prospectively included at {T}angui & eacute;ta, {B}enin. {A} {WBCT} with a sequential reading (i.e., at 20, 30, and 60 min), viscoelastic analysis ({VA}) using the {Q}uantra analyzer, and blood count were performed on admission. {VA} and the {WBCT} were also assessed at 4, 8, 12, 24, 48, and 72 h after antivenom administration. {N}ineteen patients were included. {O}n admission, the main results were an absence of a clot on {VA} and a slight decrease in platelets. {C}lot time gradually decreased over time while clot stiffness, fibrinogen, and platelet contributions to stiffness increased. {S}equential reading improved the sensitivity of the {WBCT}. {A}t {H}48, all patients with recurrence bleeding after antivenom administration had an abnormal {WBCT} while patients with a normal {WBCT} never had bleeding during their follow-up. {VA} allows the identification of various hemostasis disorders. {H}ypofibrinogenemia was the main disorder that persisted for several days after treatment. {A} {WBCT} with a sequential reading is an effective alternative for monitoring hypocoagulability in the absence of a laboratory.},
  keywords = {viscoelastic assay ; {Q}uantra ; fibrinogen ; coagulation ; fibrinolysis ; platelets ; whole blood clotting test ; antivenom ; {BENIN}},
  booktitle = {},
  journal = {{T}oxins},
  volume = {17},
  numero = {1},
  pages = {3 [19 p.]},
  year = {2025},
  DOI = {10.3390/toxins17010003},
  URL = {https://www.documentation.ird.fr/hor/fdi:010092666},
}