@article{fdi:010092660,
  title = {{E}co-friendly extraction of phlorotannins from {P}adina pavonica : identification related to purification methods towards innovative cosmetic applications},
  author = {{N}our, {M}. and {S}tiger-{P}ouvreau, {V}. and {G}uenneguez, {A}lain and {M}eslet-{C}ladi{\`e}re, {L}. and {C}{\'e}rantola, {S}. and {A}li, {A}. and {S}imon, {G}. and {D}aher, {A}. and {P}etek, {S}ylvain},
  editor = {},
  language = {{ENG}},
  abstract = {{T}his study focuses on developing innovative and eco-friendly purification methods for the isolation of bioactive compounds derived from {P}adina pavonica, a brown abundant macroalga in {D}jibouti. {T}hree distinct fractions, obtained via liquid-liquid extraction ({LLE}_{FAE}), solid-phase extraction ({SPE}_{WE}50), and flash chromatography ({FC}_{E}t{OH}20), were selected based on their high phenolic content and antioxidant activities. {A}ll fractions were also evaluated for their anti-ageing potential by assessing their ability to inhibit two vital skin-ageing enzymes, tyrosinase and elastase. {S}tructural analysis by 1{H}-13{C} {HMBC} {NMR} and {LC}-{MS} revealed a selectivity of phlorotannins depending on the purification methods. {T}he {LLE}_{FAE} fraction exhibited greater structural complexity, including compounds such as phloroglucinol, diphlorethol/difucol, fucophlorethol and bifuhalol, which likely contribute to its enhanced bioactivity compared to the fractions obtained by {FC}_{E}t{OH}20 and {SPE}_{WE}50, which were also active and enriched only in phloroglucinol and fucophlorethol. {T}hese findings highlight the impact of purification techniques on the selective enrichment of specific bioactive compounds and demonstrated the interest of {FC} or {SPE} in producing active phlorotannin-enriched fractions. {T}hese two purification methods hold strong potential for innovative cosmeceutical applications. {R}esults are discussed regarding the use of {P}. pavonica as a promising marine resource in {D}jibouti to be used for the development of cosmetic industry.},
  keywords = {antioxidants ; eco-friendly extraction ; phenolic compounds ; {LC}-{MS} ; {NMR} ; cosmeceuticals ; skin aging ; {DJIBOUTI}},
  booktitle = {},
  journal = {{M}arine {D}rugs},
  volume = {23},
  numero = {1},
  pages = {15 [24 p.]},
  year = {2025},
  DOI = {10.3390/md23010015},
  URL = {https://www.documentation.ird.fr/hor/fdi:010092660},
}