@article{fdi:010092616,
  title = {{D}ynamics of persistent submicroscopic and microscopic {P}lasmodium falciparum in pregnant women under intermittent preventive treatment : a study cohort in {B}enin},
  author = {{G}uemouri, {S}ayeh and {D}{\'e}gb{\`e}gni, {R}. and {C}ourtois, {L}. and {A}ccrombessi, {M}. and {M}assougbodji, {A}. and {D}ing, {X}. {C}. and {T}uikue {N}dam, {N}icaise and {M}ama, {A}. and {F}ievet, {N}adine and {S}arrasin-{H}ubert, {V}. and {C}otrell, {G}. and {B}riand, {V}al{\'e}rie},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {M}alaria infections in pregnancy are a major cause of maternal morbidity and neonatal mortality in sub-{S}aharan {A}frica. {A} high proportion of these infections are submicroscopic, which are usually asymptomatic and therefore untreated during pregnancy. {I}ntermittent preventive treatment with sulfadoxine-pyrimethamine ({IPT}p-{SP}) aims to prevent and treat all potential infections whether submicroscopic or not. {H}owever, the resistance of parasites to {SP} is steadily increasing. {T}he dynamic of microscopic and submicroscopic infections in a cohort of {B}eninese women throughout their pregnancy and its relation to {IPT}p-{SP} has been assessed.{M}ethods {A}s a subsample of the {RECIPAL} project, 130 women with at least 2 infections detected by polymerase chain reaction during their pregnancy were included. {I}nfections were categorized as new (isolated) or persistent based on msp-2 genotyping, where persistent infections had identical genotypes in all studied time points. {S}ubmicroscopic infections were defined as polymerase chain reaction-positive and thick blood smear-negative. {T}he persistence of infections according to {IPT}p-{SP} uptake was assessed.{R}esults {A} total of 73.1% of women (95 women of 130) had exclusively persistent infections throughout their pregnancy, whereas only 7.7% (10 of 130) had exclusively new infections. {D}uring pregnancy, the median time spent with 1 persistent infection was 7.2 weeks. {A} considerable proportion of these persistent infections 64.3% (72 of 113) was only submicroscopic. {A}pproximately 20% of these persistent infections occurred despite the use of {IPT}p-{SP}.{C}onclusions {U}sing new antimalarial combinations could contribute to limit the persistence of submicroscopic infections and their probable negative effects on the mother and the fetus. {I}ntermittent preventive treatment with sulfadoxine-pyrimethamine prevents malaria in pregnant women in {A}frica. {A} sensitive genotyping method shows that a considerable number of women have persistent infections throughout pregnancy despite this treatment. {U}sing new antimalarial combinations could contribute to limit this persistence.},
  keywords = {intermittent preventive treatment ; msp-2 fragment analysis method ; plasmodium falciparum ; pregnancy ; submicroscopic ; {BENIN} ; {AFRIQUE} {SUBSAHARIENNE}},
  booktitle = {},
  journal = {{O}pen {F}orum {I}nfectious {D}iseases},
  volume = {12},
  numero = {1},
  pages = {ofae762 [9 p.]},
  ISSN = {2328-8957},
  year = {2025},
  DOI = {10.1093/ofid/ofae762},
  URL = {https://www.documentation.ird.fr/hor/fdi:010092616},
}