@article{fdi:010092496,
  title = {{P}olyphenol content, antioxidant and antiproliferative effects of a plant mixture composed of four medicinal plants with hepatoprotective potential},
  author = {{R}ainatou, {B}. and {A}bdourahim, {K}. and {K}adiatou, {T}.{T}. and {E}sther {B}elem-{K}abr{\'e}, {W}.{L}.{M}. and {L}assina, {B}. and {S}ouleymane, {C}. and {M}oussa, {C}. and {C}arraz, {M}a{\¨e}lle and {N}oufou, {O}.},
  editor = {},
  language = {{ENG}},
  abstract = {{R}eactive oxygen species ({ROS}), known as normal by-products of various cellular processes, are involved in several human diseases, including cancer and liver diseases. {T}he present study aimed to (i) determine the polyphenol contents, (ii) assess the antioxidant, and (iii) antiproliferative effects of a mixture composed of {B}alanites aegyptiaca, {C}alotropis procera, {C}ochlospermum tinctorium, and {A}canthospermum hispidum. {T}hese plants are reported to elicit various properties, including antioxidant, hepatoprotective, and anticancer. {T}he phytochemicals were screened qualitatively, and {F}olin and {C}iocalteu as well as aluminium chloride were used as reagents, to measure the total phenolics ({TPC}) and flavonoids ({TFC}), respectively. {T}he antioxidant assay used four assays: {DPPH}, {ABTS}, {FRAP}, and {LPO}. {T}he antiproliferative effect of the mixture was investigated on the human hepatocarcinoma cell line {H}ep3{B}. {T}he phytochemical screening revealed the presence of saponins, flavonoids, tannins, sterols, coumarins, and triterpenes. {T}he mixture seems richer in total phenolics (208.81 ± 1.13 mg {GAE}/g extract) than flavonoids (10.74 ± 1.44 mg {QE}/g extract). {R}egarding the radical scavenging activity, the mixture significantly inhibited {ABTS} radicals with an {IC} 50 value of 11.61 ± 0.0006 ?g/ml. {M}oreover, it was potent in reducing ferric iron (133.06 mol {AAE}/g) and inhibiting lipid peroxidation (inhibition percentage equal to 56.39%). {T}he mixture showed a considerable antiproliferative effect against the {H}ep3{B} cells with an {IC}50 value of 1.1 ± 0.75 ?g/m{L} {T}he beneficial effects attributed to the mixture may be explained by the presence of phenolics known for their potent antioxidant properties. {T}he study findings suggest a promising synergistic plant combination for protecting the liver from oxidative stress and cancer. {H}owever, more detailed studies are needed to identify and confirm the antioxidant and antiproliferative mechanisms of action.},
  keywords = {{BURKINA} {FASO}},
  booktitle = {},
  journal = {{A}frican {J}ournal of {P}harmacy and {P}harmacology},
  volume = {17},
  numero = {9},
  pages = {182--190},
  ISSN = {1996-0816},
  year = {2023},
  DOI = {10.5897/ajpp2023.5369},
  URL = {https://www.documentation.ird.fr/hor/fdi:010092496},
}