@article{fdi:010092223,
  title = {{A} large-scale serological survey in pets from october 2020 through june 2021 in {F}rance shows significantly higher exposure to {SARS}-{C}o{V}-2 in cats compared to dogs},
  author = {{F}ritz, {M}atthieu and {E}lguero, {E}ric and {B}ecquart, {P}ierre and de {F}onclare, {D}. {D}. and {G}arcia, {D}. and {B}eurlet, {S}. and {D}enolly, {S}. and {B}oson, {B}. and {R}osolen, {S}. {G}. and {C}osset, {F}. {L}. and {B}riend-{M}archal, {A}. and {L}egros, {V}. and {L}eroy, {E}ric},
  editor = {},
  language = {{ENG}},
  abstract = {{I}ntroduction {S}evere acute respiratory syndrome coronavirus 2 ({SARS}-{C}o{V}-2) has the potential to infect various animals, including domestic pets like dogs and cats. {M}any studies have documented infection in companion animals by molecular and serological methods. {H}owever, only a few have compared seroprevalence in cats and dogs from the general population, and these studies were limited by small sample sizes and collections over short periods. {O}ur aim was to obtain a more accurate evaluation of seroprevalence in companion animals in {F}rance and to determine whether cats and dogs differ in their exposure to {SARS}-{C}o{V}-2. {M}ethods {W}e conducted an extensive serological survey of {SARS}-{C}o{V}-2, collecting blood samples from 2036 cats and 3577 dogs during routine veterinary medical examinations across different regions of metropolitan {F}rance from {O}ctober 2020 to {J}une 2021. {T}his period encompassed the peaks and onset of two waves, as well as the emergence of the first variants. {A} microsphere immunoassay targeting the receptor-binding domain and trimeric spike protein was used to detect anti-{SARS}-{C}o{V}-2 antibodies. {A} subset of 308 seropositive samples was tested for the presence of neutralising antibodies. {R}esults {W}e determined an overall seroprevalence of anti-{SARS}-{C}o{V}-2 antibodies of 7.1% (95% confidence interval [{CI}]: 6.4%-7.8%) among the sampled pets. {C}ats exhibited a significantly higher seroprevalence (9.3%; 95% {CI}: 8.1%-10.1%) compared to dogs (5.9%; 95% {CI}: 5.2%-6.8%). {A}mong the subset of seropositive samples, 81 (26.3%; 95% {CI}: 21.5%-31.6%) displayed neutralizing antibodies. {F}urthermore, seroprevalence in both species was lower in older animals and was not associated with sex. {F}inally, unlike cats, seroprevalence in dogs was found to be correlated with the date of sampling.{C}onclusions{T}he large sample size enhances the reliability and statistical robustness of our estimates regarding pet exposure to {SARS}-{C}o{V}-2. {T}his study on {SARS}-{C}o{V}-2 reaffirms the crucial importance of adopting a {O}ne {H}ealth approach incorporating domestic animals when managing an epidemic caused by a zoonotic virus.},
  keywords = {microsphere immunoassay ; neutralisation assay ; one health ; pets ; {SARS}-{C}o{V}-2 ; serology ; {FRANCE}},
  booktitle = {},
  journal = {{Z}oonoses and {P}ublic {H}ealth},
  volume = {[{E}arly access]},
  numero = {},
  pages = {[10 p.]},
  ISSN = {1863-1959},
  year = {2024},
  DOI = {10.1111/zph.13198},
  URL = {https://www.documentation.ird.fr/hor/fdi:010092223},
}