%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Mosnier, E.
%A Ségéral, O.
%A Neth, S.
%A Sagaon Teyssier, Luis
%A Khuon, D.
%A Phoeung, C. L.
%A Mam, S.
%A Chhay, C.
%A Heang, K.
%A Duclos-Vallée, J. C.
%A Saphonn, V.
%T Community versus facility-based services to improve the screening of active hepatitis C virus infection in Cambodia : the ANRS 12384 CAM-C cluster randomized controlled trial-protocol for a mixed methods study
%D 2024
%L fdi:010092157
%G ENG
%J JMIR Research Protocols
%@ 1929-0748
%K hepatitis C virus ; HCV ; community-based intervention ; cluster randomized ; controlled trial ; Cambodia ; cost-effectiveness analysis ; qualitative ; analysis
%K CAMBODGE
%M ISI:001368059200004
%P e63376 [11 ]
%R 10.2196/63376
%U https://www.documentation.ird.fr/hor/fdi:010092157
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2025-01/010092157.pdf
%V 13
%W Horizon (IRD)
%X Background : In Cambodia, hepatitis C constitutes a significant public health challenge, particularly among older adults (>45years) for whom prevalence is estimated to be 5%. To facilitate the elimination of hepatitis C among the general population, enhancing access to screening and treatment is imperative. In this regard, the evaluation of community-based screening programs emerges as a crucial step toward improving health care accessibility. Objective : This study aims to assess the comparative efficacy of a community-based versus a facility-based approach in enhancing the uptake of hepatitis C antibody testing among the general population older than 40 years of age in Cambodia. Methods : The CAM-C (Community Versus Facility-Based Services to Improve the Screening of Active Hepatitis C Virus Infection in Cambodia) study uses a cluster-randomized controlled trial design across two Cambodian provinces to compare community-based and facility-based hepatitis testing interventions. Sampling involves a multistage cluster approach, targeting individuals older than 40 years of age due to their higher prevalence and risk of chronic hepatitis complications. This study incorporates a qualitative analysis of acceptability and a cost-effectiveness comparison. Interventions include facility-based testing with subsequent referral and community-based testing with direct in-home assessments. Follow-up for positive cases involves comprehensive management and potential direct-acting antiviral treatment. This study aims to identify a significant increase in testing uptake, requiring the screening of 6000 individuals older than 40 years of age, facilitated by a structured sampling and intervention approach to minimize contamination risks. Results : The final protocol including the quantitative, qualitative, and cost-effectiveness part of the study was registered and was approved in 2019 by the National Ethical Cambodian for Health Research. Inclusions were completed by mid-2024, with analyses starting in May 2024 Conclusions : Using a mixed methods approach that combines a robust methodology (cluster-randomized controlled trial) with a cost-effectiveness analysis and qualitative research, such a study should provide invaluable information to guide the Ministry of Health in its hepatitis C virus screening strategy and move toward elimination.
%$ 056