@article{fdi:010092157,
  title = {{C}ommunity versus facility-based services to improve the screening of active hepatitis {C} virus infection in {C}ambodia : the {ANRS} 12384 {CAM}-{C} cluster randomized controlled trial-protocol for a mixed methods study},
  author = {{M}osnier, {E}. and {S}{\'e}g{\'e}ral, {O}. and {N}eth, {S}. and {S}agaon {T}eyssier, {L}uis and {K}huon, {D}. and {P}hoeung, {C}. {L}. and {M}am, {S}. and {C}hhay, {C}. and {H}eang, {K}. and {D}uclos-{V}all{\'e}e, {J}. {C}. and {S}aphonn, {V}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground : {I}n {C}ambodia, hepatitis {C} constitutes a significant public health challenge, particularly among older adults (>45years) for whom prevalence is estimated to be 5%. {T}o facilitate the elimination of hepatitis {C} among the general population, enhancing access to screening and treatment is imperative. {I}n this regard, the evaluation of community-based screening programs emerges as a crucial step toward improving health care accessibility. {O}bjective : {T}his study aims to assess the comparative efficacy of a community-based versus a facility-based approach in enhancing the uptake of hepatitis {C} antibody testing among the general population older than 40 years of age in {C}ambodia. {M}ethods : {T}he {CAM}-{C} ({C}ommunity {V}ersus {F}acility-{B}ased {S}ervices to {I}mprove the {S}creening of {A}ctive {H}epatitis {C} {V}irus {I}nfection in {C}ambodia) study uses a cluster-randomized controlled trial design across two {C}ambodian provinces to compare community-based and facility-based hepatitis testing interventions. {S}ampling involves a multistage cluster approach, targeting individuals older than 40 years of age due to their higher prevalence and risk of chronic hepatitis complications. {T}his study incorporates a qualitative analysis of acceptability and a cost-effectiveness comparison. {I}nterventions include facility-based testing with subsequent referral and community-based testing with direct in-home assessments. {F}ollow-up for positive cases involves comprehensive management and potential direct-acting antiviral treatment. {T}his study aims to identify a significant increase in testing uptake, requiring the screening of 6000 individuals older than 40 years of age, facilitated by a structured sampling and intervention approach to minimize contamination risks. {R}esults : {T}he final protocol including the quantitative, qualitative, and cost-effectiveness part of the study was registered and was approved in 2019 by the {N}ational {E}thical {C}ambodian for {H}ealth {R}esearch. {I}nclusions were completed by mid-2024, with analyses starting in {M}ay 2024 {C}onclusions : {U}sing a mixed methods approach that combines a robust methodology (cluster-randomized controlled trial) with a cost-effectiveness analysis and qualitative research, such a study should provide invaluable information to guide the {M}inistry of {H}ealth in its hepatitis {C} virus screening strategy and move toward elimination.},
  keywords = {hepatitis {C} virus ; {HCV} ; community-based intervention ; cluster randomized ; controlled trial ; {C}ambodia ; cost-effectiveness analysis ; qualitative ; analysis ; {CAMBODGE}},
  booktitle = {},
  journal = {{JMIR} {R}esearch {P}rotocols},
  volume = {13},
  numero = {},
  pages = {e63376 [11 ]},
  ISSN = {1929-0748},
  year = {2024},
  DOI = {10.2196/63376},
  URL = {https://www.documentation.ird.fr/hor/fdi:010092157},
}