@article{fdi:010092066,
  title = {{T}he helper strategy in vector-transmission of plant viruses},
  author = {{D}i {M}attia, {J}. and {Z}eddam, {J}ean-{L}ouis and {U}zest, {M}. and {B}lanc, {S}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A}n intriguing aspect of vector-transmission of plant viruses is the frequent involvement of a helper component ({HC}). {HC}s are virus-encoded non-structural proteins produced in infected plant cells that are mandatory for the transmission success. {O}ver five decades, all data collected on {HC}s from unrelated viral species transmitted by distinct vector species were consistent with a unique mode of action designated "the bridge hypothesis": the {HC} has two functional domains, one binding the virus particle and the other binding a putative receptor in the vector, creating a reversible molecular bridge between the two. {T}his hypothesis appeared fully satisfactory as {HC}s were reported solely in viruses transmitted non-circulatively - i.e. the virus particle binds externally to the mouthpart of its vector, and can later be released therefrom and inoculated. {R}ecently, however, {HC}s have also been reported in viruses transmitted circulatively, where the virus particles are internalized in gut cells and cycle within the body to reach the salivary glands. {I}n this more complex scheme of virus-vector interaction, a simple mode of action of {HC} compatible with the bridge hypothesis becomes questionable. {I}n addition, while it had consistently been shown that the sequential acquisition of {HC} and virus particles could only work when {HC} was acquired first, a recent report shows that the reverse acquisition sequence can work in some case, again questioning the bridge hypothesis as a universal mode of action. {B}ecause of the importance of {HC} molecules in the vector- transmission of plant viruses, we here propose an exhaustive review of the field, of its historical perspective and most recent development.},
  keywords = {},
  booktitle = {},
  journal = {{P}eer {C}ommunity {J}ournal},
  volume = {3},
  numero = {},
  pages = {e32 [20 p.]},
  ISSN = {2804-3871},
  year = {2023},
  DOI = {10.24072/pcjournal.258},
  URL = {https://www.documentation.ird.fr/hor/fdi:010092066},
}