@article{fdi:010092061,
  title = {{U}ntargeted metabolomics to investigate the influence of epigenetic modifiers on the metabolism of {F}usarium verticillioides},
  author = {{G}roppi, {E}. and {G}adea, {A}. and {M}onge, {C}. and {C}ristofoli, {V}. and {V}ansteelandt, {M}. and {H}addad, {M}ohamed},
  editor = {},
  language = {{ENG}},
  abstract = {{T}oxigenic fungi are capable of producing toxic metabolites, called mycotoxins. {B}ut the presence of silent and lowly expressed genes represents the main challenge for the discovery of novel mycotoxins, especially their lesser-known forms, commonly referred to as "emerging mycotoxins." {E}pigenetic modifiers ({EM}s) are compounds that are able to alter the production of metabolites through the induction of silent biosynthetic pathways leading to an enhanced chemical diversity. {T}he aim of this study was to assess the effects of different chemical modulators on the metabolic profiles of the well-known toxigenic fungal species, {F}usarium verticillioides. {F}our {EM}s, 5-azacytidine, sodium butyrate, nicotinamide ({NIC}), and sodium valproate ({SV}), were used. {F}ollowing their addition to {F}usarium verticillioides cultures, the metabolic profiles were analyzed by using {UHPLC}-{HRMS}/{MS} under targeted and untargeted metabolomics approaches. {M}etabolites were putatively annotated through the use of {MS}-{DIAL} and {MS}-{FINDER}. {O}ur results show that the treatment with {SV} induced the most important alteration of the secondary metabolic profile of {F}. verticillioides, by promoting the expression of cryptic genes. {A}mong the 50 most discriminating metabolites across five culture conditions, 12 were fusarins or fusarin analogs. {I}n contrast, {SB} and {NIC} had little impact on these metabolites. {T}he study highlights {SV}'s ability to alter gene expression by inhibiting {DNA} deacetylation in fungal strains. {T}his research could have significant implications for agriculture and food industry, especially in regions facing major mycotoxin challenges.},
  keywords = {},
  booktitle = {},
  journal = {{I}nternational {J}ournal of {M}icrobiology},
  volume = {2024},
  numero = {},
  pages = {1763495 [14 p.]},
  ISSN = {1687-918{X}},
  year = {2024},
  DOI = {10.1155/2024/1763495},
  URL = {https://www.documentation.ird.fr/hor/fdi:010092061},
}