Sinane M. auteur aut IRD Grunberger Colin auteur aut IRD Gentile L. auteur aut IRD Moriou C. auteur aut IRD Chaker V. auteur aut IRD Coutrot P. auteur aut IRD Guenneguez Alain auteur aut IRD Poullaouec M. A. auteur aut IRD Connan S. auteur aut IRD Stiger-Pouvreau V. auteur aut IRD Zubia M. auteur aut IRD Fleury Y. auteur aut IRD Cérantola S. auteur aut IRD Kervarec N. auteur aut IRD Al-Mourabit A. auteur aut IRD Petek Sylvain auteur aut IRD Voisset C. auteur aut IRD text journalArticle eng text/pdf reformatted digital access The screening of 166 extracts from tropical marine organisms (invertebrates, macroalgae) and 3 cyclolipopeptides from microorganisms against yeast prions highlighted the potential of Verongiida sponges to prevent the propagation of prions. We isolated the known compounds purealidin Q (1), aplysamine-2 (2), pseudoceratinine A (3), aerophobin-2 (4), aplysamine-1 (5), and pseudoceratinine B (6) for the first time from the Wallisian sponge Suberea laboutei. We then tested compounds 1-6 and sixteen other bromotyrosine and bromophenol derivatives previously isolated from Verongiida sponges against yeast prions, demonstrating the potential of 1-3, 5, 6, aplyzanzine C (7), purealidin A (10), psammaplysenes D (11) and F (12), anomoian F (14), and N,N-dimethyldibromotyramine (15). Following biological tests on mammalian cells, we report here the identification of the hitherto unknown ability of the six bromotyrosine derivatives 1, 2, 5, 7, 11, and 14 of marine origin to reduce the spread of the PrPSc prion and the ability of compounds 1 and 2 to reduce endoplasmic reticulum stress. These two biological activities of these bromotyrosine derivatives are, to our knowledge, described here for the first time, offering a new therapeutic perspective for patients suffering from prion diseases that are presently untreatable and consequently fatal. specialized marine sponges prion diseases yeast-based screening PrPSc ER stress bromotyrosine derivatives Verongiida Suberea laboutei POLYNESIE FRANCAISE WALLIS ET FUTUNA 035 22 10 456 [18 p.] 2024 https://www.documentation.ird.fr/hor/fdi:010092038 10.3390/md22100456 [F B010092038] https://www.documentation.ird.fr/hor/fdi:010092038 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2024-12/010092038.pdf IRD - Base Horizon / Pleins textes 2024-12-04 2025-11-06 fdi:010092038 fre