@article{fdi:010092038,
  title = {{P}otential of marine sponge metabolites against prions : bromotyrosine derivatives, a family of interest},
  author = {{S}inane, {M}. and {G}runberger, {C}olin and {G}entile, {L}. and {M}oriou, {C}. and {C}haker, {V}. and {C}outrot, {P}. and {G}uenneguez, {A}lain and {P}oullaouec, {M}. {A}. and {C}onnan, {S}. and {S}tiger-{P}ouvreau, {V}. and {Z}ubia, {M}. and {F}leury, {Y}. and {C}{\'e}rantola, {S}. and {K}ervarec, {N}. and {A}l-{M}ourabit, {A}. and {P}etek, {S}ylvain and {V}oisset, {C}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he screening of 166 extracts from tropical marine organisms (invertebrates, macroalgae) and 3 cyclolipopeptides from microorganisms against yeast prions highlighted the potential of {V}erongiida sponges to prevent the propagation of prions. {W}e isolated the known compounds purealidin {Q} (1), aplysamine-2 (2), pseudoceratinine {A} (3), aerophobin-2 (4), aplysamine-1 (5), and pseudoceratinine {B} (6) for the first time from the {W}allisian sponge {S}uberea laboutei. {W}e then tested compounds 1-6 and sixteen other bromotyrosine and bromophenol derivatives previously isolated from {V}erongiida sponges against yeast prions, demonstrating the potential of 1-3, 5, 6, aplyzanzine {C} (7), purealidin {A} (10), psammaplysenes {D} (11) and {F} (12), anomoian {F} (14), and {N},{N}-dimethyldibromotyramine (15). {F}ollowing biological tests on mammalian cells, we report here the identification of the hitherto unknown ability of the six bromotyrosine derivatives 1, 2, 5, 7, 11, and 14 of marine origin to reduce the spread of the {P}r{PS}c prion and the ability of compounds 1 and 2 to reduce endoplasmic reticulum stress. {T}hese two biological activities of these bromotyrosine derivatives are, to our knowledge, described here for the first time, offering a new therapeutic perspective for patients suffering from prion diseases that are presently untreatable and consequently fatal.},
  keywords = {marine sponges ; prion diseases ; yeast-based screening ; {P}r{PS}c ; {ER} stress ; bromotyrosine derivatives ; {V}erongiida ; {S}uberea laboutei ; {POLYNESIE} {FRANCAISE} ; {WALLIS} {ET} {FUTUNA}},
  booktitle = {},
  journal = {{M}arine {D}rugs},
  volume = {22},
  numero = {10},
  pages = {456 [18 p.]},
  year = {2024},
  DOI = {10.3390/md22100456},
  URL = {https://www.documentation.ird.fr/hor/fdi:010092038},
}