@article{fdi:010092027,
  title = {{U}nveiling the substrate-dependent dynamics of mycotoxin production in {F}usarium verticillioides using an {OSMAC}-metabolomics approach},
  author = {{G}roppi, {E}. and {H}addad, {M}ohamed and {C}ristofoli, {V}. and {V}ansteelandt, {M}. and {G}adea, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{F}usarium verticillioides is a prevalent plant pathogenic fungus known to produce harmful mycotoxins, including fumonisins and emerging toxins. {T}his study aimed to investigate the influence of substrate on the temporal patterns of mycotoxin biosynthesis by {F}. verticillioides, employing a combined {OSMAC} ({O}ne {S}train-{M}any {C}ompounds) strategy and metabolomics approach. {T}he fungus was cultured under various media conditions, and samples were collected over time. {LC}-{MS}/{MS} analyses and a dereplicative workflow were used to profile the secondary metabolite production, focusing on mycotoxins. {T}he results demonstrated that modifying the culture conditions led to significant variations in fungal growth and the nature and relative concentrations of mycotoxins produced. {C}orn meal agar ({CMA}) medium was favorable for fumonisins {A}1 and {B}1, while malt extract agar ({MEA}) favored fumonisins {A}2 and {B}2. {T}he study also identified the production of other mycotoxins related compounds as fusarins, bikaverin derivatives and fumonisins analogs, under different growth conditions. {T}his study highlights the potential of combining {OSMAC} and metabolomics to unravel the substrate-dependent and time-dependent variations in mycotoxin biosynthesis by {F}. verticillioides. {T}he insights gained provide a better understanding of the ecophysiology of this fungus and the occurrence of its mycotoxins, which can inform targeted mitigation strategies to ensure food and feed safety.},
  keywords = {fumonisins ; {F}usarium verticillioides ; metabolomics ; one strain many compounds approach ({OSMAC}) ; emerging mycotoxins},
  booktitle = {},
  journal = {{C}hemistry and {B}iodiversity},
  volume = {22},
  numero = {1},
  pages = {e202401747 [9 ]},
  ISSN = {1612-1872},
  year = {2025},
  DOI = {10.1002/cbdv.202401747},
  URL = {https://www.documentation.ird.fr/hor/fdi:010092027},
}