@article{fdi:010091931,
  title = {{T}rajectory of cognitive decline before and after stroke in 14 population cohorts},
  author = {{L}o, {J}. {W}. and {C}rawford, {J}. {D}. and {L}ipnicki, {D}. {M}. and {L}ipton, {R}. {B}. and {K}atz, {M}. {J}. and {P}reux, {P}. {M}. and {G}uerchet, {M}a{\¨e}lenn and d'{O}rsi, {E}. and {Q}uialheiro, {A}. and {R}ech, {C}. {R}. and {R}itchie, {K}. and {S}koog, {I}. and {N}ajar, {J}. and {S}terner, {T}. {R}. and {R}olandi, {E}. and {D}avin, {A}. and {R}ossi, {M}. and {R}iedel-{H}eller, {S}. {G}. and {P}abst, {A}. and {R}oehr, {S}. and {G}anguli, {M}. and {J}acobsen, {E}. and {S}nitz, {B}. {E}. and {A}nstey, {K}. {J}. and {A}iello, {A}. {E}. and {B}rodaty, {H}. and {K}ochan, {N}. {A}. and {C}hen, {Y}. {C}. and {C}hen, {J}. {H}. and {S}anchez-{J}uan, {P}. and del {S}er, {T}. and {V}alenti, {M}. and {L}obo, {A}. and {D}e-la-{C}ámara, {C}. and {L}obo, {E}. and {S}achdev, {P}. {S}.},
  editor = {},
  language = {{ENG}},
  abstract = {{I}mportance {P}oststroke cognitive impairment is common, but the cognitive trajectory following a first stroke, relative to prestroke cognitive function, remains unclear. {O}bjective {T}o map the trajectory of cognitive function before any stroke and after stroke in global cognition and in 4 cognitive domains, as well as to compare the cognitive trajectory prestroke in stroke survivors with the trajectory of individuals without incident stroke over follow-up. {D}esign, {S}etting, and {P}articipants {T}he study used harmonized and pooled data from 14 population-based cohort studies included in the {C}ohort {S}tudies of {M}emory in an {I}nternational {C}onsortium collaboration. {T}hese studies were conducted from 1993 to 2019 across 11 countries among community-dwelling older adults without a history of stroke or dementia. {F}or this study, linear mixed-effects models were used to estimate trajectories of cognitive function poststroke relative to a stroke-free cognitive trajectory. {T}he full model adjusted for demographic and vascular risk factors. {D}ata were analyzed from {J}uly 2022 to {M}arch 2024. {E}xposure {I}ncident stroke. {M}ain outcomes and measures {T}he primary outcome was global cognition, defined as the standardized average of 4 cognitive domains (language, memory, processing speed, and executive function). {C}ognitive domain scores were formed by selecting the most commonly administered test within each domain and standardizing the scores. {R}esults {T}he study included 20 860 participants (12 261 [58.8%] female) with a mean ({SD}) age of 72.9 (8.0) years and follow-up of 7.51 (4.2) years. {I}ncident stroke was associated with a substantial acute decline in global cognition (-0.25 {SD}; 95% {CI}, -0.33 to -0.17 {SD}), the {M}ini-{M}ental {S}tate {E}xamination, and all cognitive domains (ranging from -0.17 {SD} to -0.22 {SD}), as well as accelerated decline in global cognition (-0.038 {SD} per year; 95% {CI}, -0.057 to -0.019 {SD} per year) and all domains except memory (ranging from -0.020 to -0.055 {SD} per year), relative to a stroke-free cognitive trajectory. {T}here was no significant difference in prestroke slope in stroke survivors compared with the rate of decline in individuals without stroke in all cognitive measures. {T}he mean rate of decline without a previous stroke was -0.049 {SD} per year (95% {CI}, -0.051 to -0.047 {SD}) in global cognition. {C}onclusions and relevance {I}n this cohort study using pooled data from 14 cohorts, incident stroke was associated with acute and accelerated long-term cognitive decline in older stroke survivors.},
  keywords = {{MONDE}},
  booktitle = {},
  journal = {{JAMA} {N}etwork {O}pen},
  volume = {7},
  numero = {10},
  pages = {e2437133 [15 ]},
  ISSN = {2574-3805},
  year = {2024},
  DOI = {10.1001/jamanetworkopen.2024.37133},
  URL = {https://www.documentation.ird.fr/hor/fdi:010091931},
}