@article{fdi:010091899,
  title = {{C}omparative analysis of the duodenojejunal microbiome with the oral and fecal microbiomes reveals its stronger association with obesity and nutrition},
  author = {{S}teinbach, {E}. and {B}elda, {E}ugeni and {A}lili, {R}. and {A}driouch, {S}. and {D}auriat, {C}. {J}. {G}. and {D}onatelli, {G}. and {D}umont, {J}. {L}. and {P}acini, {F}. and {T}uszynski, {T}. and {P}elloux, {V}. and {J}acques, {F}. and {C}reusot, {L}. and {C}oles, {E}. and {T}aillandier, {P}. and {G}omez, {M}. {V}. and {M}asi, {D}. and {M}ateo, {V}. and {A}ndr{\'e}, {S}. and {K}ordahi, {M}. and {R}ouault, {C}. and {Z}ucker, {J}ean-{D}aniel and {S}okol, {H}. and {G}enser, {L}. and {C}hassaing, {B}. and {L}e {R}oy, {T}. and {C}l{\'e}ment, {K}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he intestinal microbiota is increasingly recognized as a crucial player in the development and maintenance of various chronic conditions, including obesity and associated metabolic diseases. {W}hile most research focuses on the fecal microbiota due to its easier accessibility, the small intestine, as a major site for nutrient sensing and absorption, warrants further investigation to determine its microbiota composition and functions. {H}ere, we conducted a clinical research project in 30 age- and sex-matched participants with (n = 15) and without (n = 15) obesity. {D}uodenojejunal fluid was obtained by aspiration during endoscopy. {P}henotyping included clinical variables related to metabolic status, lifestyle, and psychosocial factors using validated questionnaires. {W}e performed metagenomic analyses of the oral, duodenojejunal, and fecal microbiome, alongside metabolomic data from duodenojejunal fluid and feces, integrating these data with clinical and lifestyle information. {O}ur results highlight significant associations between duodenojejunal microbiota composition and usual dietary intake, as well as clinical phenotypes, with larger effect sizes than the associations between these variables and fecal microbiota. {N}otably, we found that the duodenojejunal microbiota of patients with obesity exhibited higher diversity and showed distinct differences in the abundance of several duodenojejunal microbiota species compared with individuals without obesity. {O}ur findings support the relevance of studying the role of the small intestinal microbiota in the pathogenesis of nutrition-related diseases.},
  keywords = {{S}mall intestine microbiota ; duodenojejunal microbiome ; oral microbiome ; microbiota ; microbiome ; nutrition ; metabolomics ; dietary quality ; obesity ; metabolic diseases},
  booktitle = {},
  journal = {{G}ut {M}icrobes},
  volume = {16},
  numero = {1},
  pages = {2405547 [19 p.]},
  ISSN = {1949-0976},
  year = {2024},
  DOI = {10.1080/19490976.2024.2405547},
  URL = {https://www.documentation.ird.fr/hor/fdi:010091899},
}