Horizon 1 1 17 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES Synthesis 1297-1308 nitroaromatic compounds imidazo[1,2-a ]pyridines kinetoplastids nucleophilic aromatic substitution palladium-catalyzed cross-coupling reactions microwave irradiation 2024 fdi:010091877 ENG Synthesis 0039-7881 ISI:001318785900001 08 10.1055/a-2232-8113 https://www.documentation.ird.fr/hor/fdi:010091877 https://www.documentation.ird.fr/intranet/publi/2024-11/010091877.pdf 56 Horizon (IRD) Figure 1 Structures of metronidazole and antikinetoplastid nitroheterocyclic drug compounds. To study the antikinetoplastid structure-activity relationships in a 3-nitroimidazo[1,2- a ]pyridine series, we explored the substitution of positions 5 and 7 of the scaffold, developing nucleophilic aromatic substitution reactions and palladium-catalyzed Suzuki-Miyaura, Sonogashira, and Buchwald-Hartwig cross-coupling reactions that had never been reported at these positions in this series. In four steps from 2-amino(bromo)pyridines, 33 original compounds were obtained, allowing a better definition of the antiparasitic pharmacophore. 020 UR152